Polarization-Independent Terahertz Surface Plasmon Resonance Biosensor for Species Identification of Panax and Paeonia

Hu, Songyan; Sun, Chuang; Wu, Xu; Peng, Yan

doi:10.3390/photonics10030250

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Li et al developed a method for the determination of OTA in Pu-erh tea using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS), with a limit of detection of 0.1 pg/mg [17]. These methods provide high accuracy and sensitivity, but there are some drawbacks, such as a time-consuming and complex pre-treatment, long period, high cost of testing, poor reproducibility, and damage of samples; therefore, they cannot meet the market requirements for rapid detection [18]. In recent years, spectroscopy techniques including UV spectrophotometry, near-infrared spectroscopy, and Raman spectroscopy have been used for the rapid detection and quantitative analysis of various compounds, providing the basis for the identification of OTA [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Rapid Determination of Ochratoxin A in Black Tea Using Terahertz Ultrasensitive Biosensor

Chen,

Liu,

et al. 2023

Photonics

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Ochratoxin A (OTA), which is highly toxic and carcinogenic, is easily produced in cereal crops, dry herbs, and other foods under improper storage. Traditional detection methods, including high-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assay (ELISA), can detect OTA accurately, but there are many problems such as long period, high cost, and poor reproducibility. Therefore, developing a rapid, non-destructive, and highly sensitive method for OTA detection is essential. In this paper, we used a surface plasmon resonance (SPR) biosensor combined with terahertz (THz) spectroscopy to quantify OTA. As a result, the concentration range of OTA in acetonitrile solution was up to 0–20 pg/μL, with a detection limit of 1 pg/μL, which can meet the requirements for OTA detection in most foods. Further, we applied this method to black tea, and the detection limit was up to 1 pg/mg, which is 500 times higher than UV spectrophotometry, and completely meets the EU regulations. This study shows that the combination of terahertz spectroscopy and an SPR biosensor is a promising approach to achieve a simple, rapid, and low-cost method for trace substance quantification in foods and drugs.

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Section: Introductionmentioning

confidence: 99%

Rapid Determination of Ochratoxin A in Black Tea Using Terahertz Ultrasensitive Biosensor

Chen,

Liu,

et al. 2023

Photonics

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Molecular structure analysis of xanthine alkaloids using terahertz spectroscopy

Wang,

Huang,

Zhang

et al. 2024

Journal of Molecular Spectroscopy

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Frequency selective fingerprint sensor: the Terahertz unity platform for broadband chiral enantiomers multiplexed signals and narrowband molecular AIT enhancement

Lyu,

Shen,

Chen

et al. 2023

PhotoniX

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Chiral enantiomers have different pharmacological and pharmacokinetic characteristics. It is important to strictly detect chiral component for avoiding being harmful to the human body due to side effects. Terahertz (THz) trace fingerprint detection is essential because the molecular vibrations of various biological substances such as chiral enantiomers are located in THz range. Recent reported enhanced trace fingerprint technologies have some drawbacks. For instance, multiplexing technology suffered from narrow operation range and limitation by frequency resolution of commercial THz time domain spectroscopy; Absorption induced transparency (AIT) identification for narrowband molecular oscillations suffered from random resonance frequency drift due to fabrication error. In this paper, we proposed frequency-selective fingerprint sensor (FSFS), which can experimentally achieve enhanced trace fingerprint detection by both broadband multiplexing technology and robust AIT identification. Such FSFS is based on polarization independent reconfiguration metasurfaces array. Broadband absorption lines of trace-amount chiral carnitine were boosted with absorption enhancement factors of about 7.3 times based on frequency-selective multiplexing at 0.95–2.0 THz. Enhanced trace narrowband α-lactose fingerprint sensing can be observed at several array structures with absorption enhancement factors of about 7 times based on AIT, exhibiting good robustness. The flexibility and versatility of proposed FSFS has potential applications for boosting trace chiral enantiomer detection as well as diversity of molecular fingerprints identification by both multiplexing and AIT.

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Polarization-Independent Terahertz Surface Plasmon Resonance Biosensor for Species Identification of Panax and Paeonia

Cited by 4 publications

References 29 publications

Rapid Determination of Ochratoxin A in Black Tea Using Terahertz Ultrasensitive Biosensor

Rapid Determination of Ochratoxin A in Black Tea Using Terahertz Ultrasensitive Biosensor

Molecular structure analysis of xanthine alkaloids using terahertz spectroscopy

Frequency selective fingerprint sensor: the Terahertz unity platform for broadband chiral enantiomers multiplexed signals and narrowband molecular AIT enhancement

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