Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)

NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis

“…Profibrotic macrophages increase the generation of profibrotic cytokines and provide substrate for collagen synthesis. Targeting this macrophage phenotype has been examined in several preclinical studies to reduce or prevent pulmonary fibrosis (3)(4)(5)(38)(39)(40). A prior study showed that NOX4 was decreased in iPLA2β −/− macrophages, which harbor a profibrotic phenotype (41).…”

Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen

“…Further evidence that lipid mediators regulate the polarization of macrophages comes from a recent report indicating that, in contrast to the loss of Pla2g10 or Pla2g5, peritoneal macrophages isolated from mice lacking iPLA 2 β (Pla2g6a) are more readily skewed toward an M2-like phenotype (71). A notable finding in our study was that the lack of Pla2g10 markedly altered the number of recruited macrophages to the lung -a significant finding, given recent studies that have demonstrated that recruited macrophages are central to the promotion of allergic inflammation (39,72), while resident macrophages, which were not altered by the loss of Pla2g10, tend to suppress allergic inflammation (73,74).…”

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

“…A resurgence of interest in bioactive lipids has been complemented with the characterization of the bioactive lipids composition of M1/M2 polarized macrophages [67]. Studies have shown that the lipidomic composition and the resulting phospholipase subtype mediated activity to influence the development of proinflammatory subtype (M1) over the anti-inflammatory subtype (M2) [67].…”

“…A resurgence of interest in bioactive lipids has been complemented with the characterization of the bioactive lipids composition of M1/M2 polarized macrophages [67]. Studies have shown that the lipidomic composition and the resulting phospholipase subtype mediated activity to influence the development of proinflammatory subtype (M1) over the anti-inflammatory subtype (M2) [67]. While it continues to be determined whether the product of 12-Lipoxygenase (12-HETE) is important for shifting the polarization of macrophages to the M2 subtypes, more work focused on the eicosanoid signaling and its relation to cell types differentiation is required.…”