Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

Iaccarino, Leonardo; Ghirardello, Anna; Zen, Margherita; Villalta, Danilo; Tincani, Anǵela; Punzi, Leonardo; Doria, Andrea

doi:10.4081/reumatismo.2012.314

Cited by 23 publications

(13 citation statements)

References 38 publications

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“…It can be speculated if the shift of T helper 1 (Th1) to T helper 2 (Th2) is the reason for UC patients to relapse during pregnancy. Pregnancy is a complex immunological state in which a bias towards Th2 protects the foetus …”

Section: Discussionmentioning

confidence: 99%

The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women

Pedersen

Bortoli

Ďuricová

et al. 2013

Aliment Pharmacol Ther

162

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Section: Discussionmentioning

confidence: 99%

The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women

Pedersen

Bortoli

Ďuricová

et al. 2013

Aliment Pharmacol Ther

162

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“…The strong contribution of maternal immune status to ASD risk could involve genetic factors and environmental influences on the developing fetus. Similar to the situation caused by the MET ‘C’ allele, mothers with autoimmune disorders fail to develop an anti-inflammatory immune system profile that typically occurs during pregnancy 67 (FIG. 1).…”

Section: Maternal Immune Contributionsmentioning

confidence: 99%

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

2015

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Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of the immune system and many maternal immune system-related risk factors — including autoimmunity, infection and fetal reactive antibodies — are associated with ASD. In addition, there is evidence of ongoing immune dysregulation in individuals with ASD and animal models of this disorder. Recently, several molecular signalling pathways have been identified that link immune activation to ASD phenotypes, including pathways downstream of cytokines, hepatocyte growth factor receptor (MET), MHCI molecules, microglia and complement factors. These findings indicate that the immune system is a point of convergence for various ASD-related genetic and environmental risk factors.

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“…anti-ApoA-1 IgG were shown to promote a dose-dependent production of proinflammatory cytokines (interleukin [IL]-6, IL-8, and TNF-α, and matrix metalloproteinase-9) [6], an inflammatory link might be suspected between higher levels of these antibodies and TA. Therefore, as these cytokines stimulate T-helper 2 polarization [20] required for a successful pregnancy [21] and no correlation with CRP was found in the present study, other factors should be considered.…”

Section: Biomed Research Internationalmentioning

confidence: 60%

“…Abortion frequently occurs when fetus is affected by chromosomal abnormalities, but it may be also favored by several maternal factors, such as extreme weight (high or low) [17], older age, unhealthy lifestyle habits [18], and chronic illnesses, particularly autoimmune diseases (e.g., SLE) [19]. Both systemic and local inflammatory processes are believed to have a central role in abortion pathophysiology [20]. Since…”

Section: Discussionmentioning

confidence: 99%

Antiapolipoprotein A-1 Autoantibody Positivity Is Associated with Threatened Abortion

Vecchiè

Bonaventura

Carbone

et al. 2020

BioMed Research International

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Background. Autoantibodies against apolipoprotein A-1 (anti-ApoA-1 IgG) were demonstrated to be associated with cardiovascular outcomes in several inflammatory diseases. As balanced inflammation is critical for uncomplicated pregnancy, we aimed to investigate the prevalence of anti-ApoA-1 IgG and anti-c-terminal ApoA-1 autoantibodies (Ac-terAA1 IgG) in a cohort of pregnant women and their potential relationship with threatened abortion (TA). Methods. Between 2012 and 2014, 371 consecutive outpatient pregnant women were included in this study and followed until delivery. Anti-ApoA-1 and anti-Ac-terAA1 IgG were measured by ELISA technique on serum samples collected between the 24th and 26th week of pregnancy. Associations with TA were tested using linear regression analysis and C-statistics. Results. Median age was 34 with a prevalence of the Caucasian ethnicity (90.5%). TA occurred in 10 women (2.7%). C-statistics indicated that anti-ApoA-1 and anti-Ac-terAA1 IgG levels upon study inclusion were predictive of TA (0.73, 95% confidence interval [CI] 0.69-0.78, p<0.001 and 0.76, 95% CI 0.71-0.80, p=0.01, respectively). At the prespecified anti-ApoA-1 IgG cutoff, the negative predictive value (NPV) was 100%. For anti-Ac-terAA1 IgG, at the optimal cutoff, the NPV was 99%. Linear regression models indicated that risk associations were independent of age and the presence of autoimmune diseases for both autoantibodies (p<0.001). Anti-Ac-terAA1 IgG-positive individuals were more frequently non-Caucasians (p=0.009). Conclusion. Anti-ApoA-1 and anti-Ac-terAA1 IgG are independently associated with TA during pregnancy with an appealing NPV. The causal biological mechanisms underlying this association as well as the possible clinical relevance of these findings require further investigations.

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Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus

Cited by 23 publications

References 38 publications

The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women

The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Antiapolipoprotein A-1 Autoantibody Positivity Is Associated with Threatened Abortion

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