As is known, the COVID-19 pandemic has caused a series of social limitations to break the spread of the infection. These limitations have not only generated severe complaints by groups of citizens, but moreover have resulted in the reinforcement of some populist activities, which are in general cynical of strategies like vaccinations, which help to stop the spread of the COVID-19 virus. While even before the occurrence of COVID-19 immunization was a conflicting topic, a number of surveys have emphasized that the sociopolitical orientation of people has a direct effect on outlooks regarding inoculation [1]. Undoubtedly, vaccinations are among the greatest successes of contemporary medicine, and presently, immunization is the most reliable method for prevention of the current pandemic, though it is not a perfect approach with unbreakable protection. But, however, the anti-vaccination effort has caused a distressing decline in immunization rates. So, it is necessary to comprehend the causes of vaccine uncertainty, and to find working policies to undo the propaganda of antivaccine believers [2]. In the present article, disregard for lack of information or anxiety as the main causes of hesitation about refusal or deferring vaccination, politicization or party-political polarization of immunization, as an astonishing integration of two unlike subjects in the contemporary epoch, has been looked over, concisely, to analyze the interrelated dynamics of vaccine resistance.