Polarizing Calcifications

Cook, Lois; Vinding, Jens; Gordon, H. W.

doi:10.1097/00000478-199702000-00021

Cited by 7 publications

(3 citation statements)

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“…Failure to observe the corresponding quantity of calcium seen in radiographs is related to the fact that calcium may occur not only as CaP but also as CaOx; the latter is not stained with hematoxylin and eosin but is readily detected by its birefringence in polarized light. 1,2,9,12 However, the presence of CaOx does not sufficiently explain the nonvisualization of calcium, which is due instead to processing of breast specimens. In previous investigations, the authors noted a possible loss of 26.2% of calcium during the processing and sectioning of breast specimens.…”

Section: Discussionmentioning

confidence: 99%

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Özer

Canda²,

Balci³

et al. 1999

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Özer

Canda²,

Balci³

et al. 1999

Acta Cytologica

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“…In the vacuum-assisted stereotactic core biopsy procedure tissue is obtained from a localized radius, so that cores without radiographic calcifications are still in close proximity to calcifications. Also, it has been previously reported that ''loss of calcifications'' from core biopsy material may result from ''calcium particles falling out of dilated ducts at the cut edge of the core biopsy'' (10,13). This theoretically could occur even prior to performance of the specimen radiograph.…”

Section: Discussionmentioning

confidence: 99%

Segregation of radiographic calcifications in stereotactic core biopsies of breast: is it necessary?

Easley

Klein

et al. 2008

Clinical Imaging

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“…In the vacuum‐assisted stereotactic core biopsy procedure tissue is obtained from a localized radius, so that cores without radiographic calcifications are still in close proximity to calcifications. Also, it has been previously reported that “loss of calcifications” from core biopsy material may result from “calcium particles falling out of dilated ducts at the cut edge of the core biopsy” (10,13). This theoretically could occur even prior to performance of the specimen radiograph.…”

Section: Discussionmentioning

confidence: 99%

Segregation of Radiographic Calcifications in Stereotactic Core Biopsies of Breast: Is It Necessary?

Easley¹,

Abdul‐Karim²,

Klein

et al. 2007

Breast Journal

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Stereotactic-needle core biopsy (SNCB) is increasingly being used for the evaluation of mammographic calcifications. Radiography of SNCB specimens is essential to confirm the presence of calcifications within the biopsy material. To aid and direct the pathologist, it has been recommended that SNCBs be separated into those with and without radiographic calcifications and separately embedded. However, the utility of this separation to the pathologist has not been established. We reviewed 80 consecutive 11 gauge vacuum-assisted SNCB procedures performed for mammographic calcifications. The core biopsies were separated by the radiologist into those with and without radiographic calcifications ("calcs" and "no calcs"). Twenty-nine of 80 (36%) of the "calcs" cores were atypical or malignant, while 23 of 80 (29%) of the "no calcs" cores were atypical or malignant (chi(2) = 0.63, p = NS). The same diagnosis was rendered in the "calcs" and "no calcs" specimens in 61/80 cases (76%). Two cases of ductal carcinoma in situ, four cases of atypical ductal hyperplasia and 13 cases of fibroadenoma were diagnosed in the "calcs" cores only. However, in all cases where the pathologic lesion was seen in the "calcs" core only, the pathologic lesion was present on initial H&E levels and would have been diagnosed even in the absence of core segregation. Deeper sections were deemed necessary in seven of the 80 cases. No change in diagnosis was made on the basis of these deeper sections, even in the cases where histologic calcifications appeared on deeper sections. Separate embedding of SNCBs into those with and without radiographic calcifications does not appear to be of great utility to the pathologist. Equal attention should be given to all cores in the setting of SNCBs for mammographic calcifications.

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Polarizing Calcifications

Cited by 7 publications

References 0 publications

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Segregation of radiographic calcifications in stereotactic core biopsies of breast: is it necessary?

Segregation of Radiographic Calcifications in Stereotactic Core Biopsies of Breast: Is It Necessary?

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