Polarographic assay of Ranitidine Drugs in Pharmaceutical Formulations

Zuhri, Ali Z. Abu; Hannoun, Mohammad; Al-Khalil, Suleiman; Hasna, Hind

doi:10.1080/00032718808066351

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…It competitively inhibits the action of histamine on the H 2 receptors of parietal cells. 1,2 There are some works in the literature that describe the use of conventional HMDE and DME electrodes to study its electrochemical reduction 1,2 and the determination of ranitidine in pharmaceutical formulations, [1][2][3][4] employing polarographic techniques, and in biological materials, 1,5 employing voltammetric techniques. The use of mercury coated ultramicroeletrodes (Hg-UMEs) is an alternative to the massive use of mercury, allowing the in situ application to biological systems of low dimension of samples which differs the present method from the photometric ones.…”

Section: Instituto De Química De São Carlos Universidade De São Paulmentioning

confidence: 99%

Determination of ranitidine in drugs using a mercury coated platinum ultramicroelectrode and hanging mercury dropping electrode

Malagutti¹,

Mazo²

2003

J. Braz. Chem. Soc.

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O comportamento voltamétrico da ranitidina foi estudado em meio aquoso utilizando um ultramicroeletrodo de platina com eletro-depósito de mercúrio (Hg-UME) e o eletrodo de gota pendente de mercúrio, HMDE. A voltametria de varredura linear (LSV) mostrou que o composto apresenta duas ondas de redução em pH < 4,0 e somente uma em pH > 4,0, sendo as ondas observadas atribuídas à redução do grupo nitro para hidroxilamina. Foi observada uma relação linear entre a corrente de pico ou corrente limite e a concentração de ranitidina utilizando o HMDE ou o Hg-UME, demonstrando que a LSV com estes eletrodos pode ser utilizada na determinação analítica de ranitidina. Uma metodologia alternativa e mais sensível para determinação analítica de ranitidina utilizando a técnica SWV também foi desenvolvida, com um limite de detecção de 3,5 x 10). Os estudos de recuperação aparente (AR) mostraram a exatidão e precisão da metodologia desenvolvida. Os excipientes encontrados nos comprimidos de marca (Glaxo Wellcome) e genérico (EMS  ) não interferiram na determinação de ranitidina.The voltammetric behavior of ranitidine has been studied in aqueous media with a mercury coated platinum ultramicroelectrode (Hg-UME) and by HMDE. The LSV curves for the electroreduction of ranitidine showed that the compound presents two reduction waves in pH < 4.0 and only one in pH > 4.0, the observed waves being attributed to the reduction of the nitro group to hydroxylamine. A linear relation between the current peak or limiting current and the ranitidine concentration using HMDE or Hg-UME was observed, demonstrating that these ultramicroelectrodes can be used in the analytical determination of ranitidine. An alternative and more sensitive methodology for the analytical determination of ranitidine by SWV was also developed, with a detection limit of 3.5 x 10 -8 mol L -1 (or 11 µg L -1). The apparent recovery (AR) studies proved the accuracy and precision of the assay developed. The excipients found in comercial Antak tablets (Glaxo Wellcome) and the generic from EMS  do not interfere in the determination.

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Section: Instituto De Química De São Carlos Universidade De São Paulmentioning

confidence: 99%

Determination of ranitidine in drugs using a mercury coated platinum ultramicroelectrode and hanging mercury dropping electrode

Malagutti¹,

Mazo²

2003

J. Braz. Chem. Soc.

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“…Thus measuring the amount of ranitidine N-oxide present in urine after administration of ranitidine has been used as a non-invasive method of determining the human liver FMO activity in vivo [8]. Several techniques such as proton magnetic resonance spectroscopy [9], near infrared refl ectance spectrometry [10], scintillation proximity assay [11], fl ow injection fl uorimetry [12], polarography [13,14], differential pulse polarography [15], capillary electrophoresis [16], high performance liquid chromatography [17,18] have been used for the determination of RNH in pharmaceuticals. These techniques require sophisticated instruments and expensive reagents, and involve several manipulation steps and derivatization reactions.…”

Section: Introductionmentioning

confidence: 99%

New reagents for the spectrophotometric determination of ranitidine hydrochloride

Narayana

Ashwani

Shetty³

2010

Eclet. Quim.

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A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer’s law is obeyed in the concentration range of 0.4-8.0 μg/ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6μg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell’s sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.

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“…Many methods such as polarography [2] differential pulse polarography [3], capillary electrophoresis (CE) [4,5], high-performance liquid chromatography (HPLC) [6 -9], fluorimetry [10], and chemiluminescence (CL) detection method [11] have been developed for ranitidine. Among these methods, the CL method for ranitidine has been given much attention due to its excellent sensitivity, wide dynamic concentration range and the simple instrumental setup.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Electrogenerated Chemiluminescence Detecting Ranitidine Based On Chemically Modifying Microenvironment of the Chemiluminescence Reaction

Zheng

Zhang

et al. 2005

Electroanalysis

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Using a graphite electrode modified with vaseline and NiO, ranitidine showed a strongly ECL enhancing effect for the weak ECL signal of electrooxidation of luminol. Based on this finding, a more sensitive ECL method for ranitidine was firstly proposed. Under the optimum experimental conditions, the ranitidine hydrochloride concentration in the range of 3.0 Â 10 À8 -9.0 Â 10 À6 mol/L was proportional to the enhancing ECL signal and offered a 9 Â 10 À9 mol/L detection limit for ranitidine hydrochloride. At the same time, based on the investigation on this ECL reaction mechanism, a new concept, to improve the suitable ECL reaction micro-environment with chemically modified electrode technique for the better analytical performances of ECL analysis was also firstly proposed.

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Polarographic assay of Ranitidine Drugs in Pharmaceutical Formulations

Cited by 10 publications

References 4 publications

Determination of ranitidine in drugs using a mercury coated platinum ultramicroelectrode and hanging mercury dropping electrode

Determination of ranitidine in drugs using a mercury coated platinum ultramicroelectrode and hanging mercury dropping electrode

New reagents for the spectrophotometric determination of ranitidine hydrochloride

Highly Sensitive Electrogenerated Chemiluminescence Detecting Ranitidine Based On Chemically Modifying Microenvironment of the Chemiluminescence Reaction

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