Polarographic determination of loratadine in pharmaceutical preparations

Stability studies on some benzocycloheptane antihistaminic agents

“…Methods have been described in the literature for the determination of loratadine whether alone or in combination with other drugs or in presence of its metabolites. The methods cited in the literature for the determination of loratadine as raw material or in dosage form (single or combined) included HPLC [3][4][5][6][7][8][9], capillary electrophoresis [10] spectrophotometric [5][6][7][11][12][13][14], polarographic [15,16] and densitometric method [7,17]. Methods used for the determination of loratadine in human plasma included HPLC [18][19][20] and a gas liquid chromatographic method [21].…”

Simultaneous determination of loratadine and desloratadine in pharmaceutical preparations using liquid chromatography with a microemulsion as eluent

“…In the literature several methods have been described for determination of LOR in pharmaceutical preparations including UV spectrophotometry [4][5][6][7][8][9][10], colorimetry [5,[11][12][13][14], spectrofluorometry [5], atomic absorption spectrometry [14], polarography [15], densitometry [6,16], capillary electrophoresis [17][18][19] and high performance liquid chromatography [4,6,7,20]. The determination of DSL in pharmaceutical preparations has only been described in one paper dealing with CE [21].…”

Nitration: A Selective Electrochemical Label for the Determination of Activated Aromatics

“…The electrochemical reduction of nitro groups has been extensively studied (10)(11)(12)(13)(14)(15)(16)(17) and this functionality has proven to be a valuable label through which many pharmaceuticals (18)(19)(20)(21)(22)(23)(24)(25)(26), pesticides/herbicides (27)(28)(29)(30)(31) and explosives (5)(6)(7)(8)32) can be detected and measured. The use of nitration as a derivatisation procedure however has largely been ignored (23,(33)(34)(35) and can be attributed to the experimental difficulties encountered in attempting to introduce the nitro group onto the target.…”

“…The use of nitration as a derivatisation procedure however has largely been ignored (23,(33)(34)(35) and can be attributed to the experimental difficulties encountered in attempting to introduce the nitro group onto the target. The need for aggressive reaction conditions and the stringent controls needed to prevent the oxidative loss of an already dilute analyte has tended reduce the viability of this approach (23,36). However, in the case of activated substrates (phenols or aromatic amines), nitration can be accomplished under considerably milder conditions that are less liable to incur material losses (23,36).…”

“…The need for aggressive reaction conditions and the stringent controls needed to prevent the oxidative loss of an already dilute analyte has tended reduce the viability of this approach (23,36). However, in the case of activated substrates (phenols or aromatic amines), nitration can be accomplished under considerably milder conditions that are less liable to incur material losses (23,36). Nitrosation under oxidising conditions has been shown to lead to a facile method for the introduction of nitro groups.…”