Polarographic Reduction of Megazol and Derivatives, and Its Polarographic, UV Spectrophotometric, and HPLC Determination

Cyclic voltammetric determination of free radical species from nitroimidazopyran: a new antituberculosis agent

“…On the other hand the second signal (II) can be ascribed to the reduction of the diazole moiety, as was previously described for other nitro imidazolic compounds [18]. Up to pH 7 the intensity of peak I decays, concomitant to the appearance of other peaks, one negative peak (III) appearing at a potential approximately 500 mV more negative than peak I and another anodic signal (IV) around )500 mV.…”

Electrochemical reduction of 2-nitroimidazole in aprotic medium: Influence of its dissociation equilibrium on the reduction mechanism

“…Nevertheless, those works are mostly focused on the electroanalytical determination of some 5-nitroimidazoles of importance in medicine such as: metronidazol [15], ornidazol [16], secnidazol [17], tinidazol [18] and megazol [19]. In addition, cyclic voltammetry has been used in the study of nitro radical anions generated by 5-nitroimidazoles such as misonidazol, metronidazol and megazol [20][21][22][23][24]. These studies demonstrated the utility of cyclic voltammetry (CV) for the study of the formation and stability of nitro radical anions.…”

Reactions of the nitro radical anion of metronidazole in aqueous and mixed solvent: a cyclic voltammetric study

“…Studies related to the electrochemical aspects of nitrocompounds are mainly focused on the electrochemical determination of these compounds [57][58][59][60][61]. Cyclic voltammetric studies that enabled the determination of lifetimes of nitro radical anions from some nitroimidazoles such as misonidazole, metronidazole, megazole, 4-nitroimidazole and ethyl-m-nitrobenzoate were also undertaken [54,[62][63][64].…”