Polarographische und voltammetrische Bestimmung anorganischer und organischer Stoffe

Henze, Günter; Neeb, Rolf

doi:10.1007/978-3-642-70173-3_3

Elektrochemische Analytik 1986

DOI: 10.1007/978-3-642-70173-3_3

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Polarographische und voltammetrische Bestimmung anorganischer und organischer Stoffe

Günter Henze

Rolf Neeb

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2002

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Sphingomyelin content conditions insertion of daunorubicin within phosphatidylcholine monolayers

2002

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Cell death induced by the chemotherapeutic drug daunorubicin (DNR) implicates an apoptotic pathway originating at the plasma membrane and characterized by sphingomyelin (SM) hydrolysis and ceramide generation. The mechanisms by which such a drug (hypothetically passively di¡using across a structural membrane) can trigger SM hydrolysis is unknown, but raises the question of the precise interaction between DNR and membrane lipid constituents. In this initial study, using alternative current polarography together with voltammetry, we report that after a ¢rst step of adsorption, insertion of DNR within a condensed phosphatidylcholine monolayer was signi¢cantly facilitated by SM content. ß

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Sphingomyelin content conditions insertion of daunorubicin within phosphatidylcholine monolayers

2002

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Polarographische und voltammetrische Bestimmung anorganischer und organischer Stoffe

Cited by 1 publication

References 473 publications

Sphingomyelin content conditions insertion of daunorubicin within phosphatidylcholine monolayers

Sphingomyelin content conditions insertion of daunorubicin within phosphatidylcholine monolayers

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