BackgroundMedicare annual wellness visits (AWVs) are prevention‐focused healthcare visits free to Medicare recipients. These visits focus on health maintenance, health risk assessment, prevention of illness, and maintaining independence, all of which are within the scope of registered nurse (RN) practice as well as aligned with what matters, medication, mentation, and mobility — the 4Ms — of age‐friendly health care. The objective of this pilot study was to evaluate the implementation of the 4Ms in the context of RN‐led Medicare AWVs in a primary care practice.MethodsIn a primary care practice with approximately 2500 patients, including approximately 571 of whom were enrolled in Medicare, RN‐led Medicare AWVs were implemented, incorporating the 4Ms framework. During this time, data were collected on the effect of the AWV on access to care—conceptualized here as the number of visits available as well as the type of clinician open to staff these visits. Data collection also included patient responses to the 4Ms question “what matters most?”ResultsOverall, the RN‐led visits were successful and beneficial to the practice. Each RN‐led visit allowed for 2 additional acute or monitoring visits per provider (nurse practitioner, MD) per day, increasing patient access to their primary care providers. Inclusion of the 4Ms questions facilitated discussion around overall mental and emotional well‐being, life stressors, quality of life, and goals of care.ConclusionRN‐led Medicare AWVs incorporating the 4Ms framework enhances the role of RNs in primary care by focusing on a health promotion role, utilizing RNs to their full scope of practice. RN‐led AWVs increase provider availability for acute and chronic care appointments, as well as foster conversations around quality of life, as well as mental and emotional well‐being.