The circulation of illegal drugs continues to increase from year to year, including during the COVID-19 pandemic. The circulation of these drugs must be disciplined and guarded so that the public is not harmed in terms of health or materially because the illegal drugs in circulation do not meet product and drug distribution standards. The research aims to explore the government's role in overcoming the distribution of drugs that are banned from circulating freely during the COVID-19 pandemic. The data comes from secondary data obtained by study documents, especially legal documents, including primary and secondary legal materials. Based on a study of the 1945 Constitution and health legislation found that the government must be responsible for tackling the circulation of drugs that are illegal from circulating freely to realize comprehensive public health. To deal with the distribution of drugs that are banned from circulating freely, the government established the Drug and Food Control Agency (BPOM) which oversees the distribution of pharmaceuticals and food in Indonesia. The supervision of drug distribution starts from the drug produced or before it is marketed (pre-market) to the drug marketing process (post-market).