Policymakers’ views on dengue fever/dengue haemorrhagic fever and the need for dengue vaccines in four southeast Asian countries

Under-recognition and reporting of dengue in Cambodia: a capture–recapture analysis of the National Dengue Surveillance System

“…5 (6) 6 . 6 (6) classification and case definition and only includes hospitalized cases [20] ; as a result, many severe cases other than those of DHF or DSS were probably missed by the NDSS [21]. As shown in this study, a substantial proportion of the overall disease incidence is represented by non-hospitalized persons who present initially with a febrile illness, which is subsequently found to be dengue.…”

“…Several dengue vaccine candidates are in the late stages of development and have entered clinical trials [2][3][4]. Once safe and effective dengue vaccines become available, robust estimates of dengue disease burden will be required in order to make decisions regarding their integration into national immunization programmes [5][6][7]. However, national surveillance data have often been shown to significantly underestimate true incidence and burden for a number of diseases.…”

Forecasting dengue vaccine demand in disease endemic and non-endemic countries

“…This is highlighted in a recent policymaker survey which suggested rapid vaccine introduction because of the perceived public health impact of dengue in many endemic countries. 15 However, it is still unknown which factors, including price and other national priorities, will facilitate or hinder the actual demand for a dengue vaccine after licensure.…”

“…Knowledge and attitudes toward dengue and dengue prevention are high in endemic countries, both among the general public and health care providers. [15][16][17] Participants in a study conducted in metropolitan Manila, Philippines, were willing to pay US$27 to US$32 per dose for a single dengue vaccine dose. 17 Demand was associated with price Tables 2 and 3.…”

“…Because outbreaks are often accompanied by media attention and often cause fear in the population, this might dramatically increase vaccine demand in both the private and public sectors. 15 Since there are no data from which to forecast control of dengue outbreaks through vaccination, studies will need to be conducted and policies and plans developed to handle this contingency.…”