Policymakers’ views regarding the introduction of new-generation vaccines against typhoid fever, shigellosis and cholera in Asia

DeRoeck, Denise; Clemens, John D.; Nyamete, Andrew; Mahoney, R. T.

doi:10.1016/j.vaccine.2004.11.044

Cited by 100 publications

(69 citation statements)

References 15 publications

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“…However, these policy makers repeated the need for regional incidence data to determine where limited resources can have the greatest impact. 27 In our qualitative interviews with policy makers and health administrators in Zanzibar, they indicated that current Health Management Information System (HMIS) surveillance data on typhoid fever was insufficient to make decisions about intervention efforts. Some policy makers and administrators also perceived the "problem" of typhoid fever as primarily restricted to mainland Tanzania.…”

Section: Discussionmentioning

confidence: 99%

Utilization and Accessibility of Healthcare on Pemba Island, Tanzania: Implications for Health Outcomes and Disease Surveillance for Typhoid Fever

Kaljee

Pach²,

Thriemer³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Salmonella enterica serotype Typhi (S. Typhi) was estimated to cause over 200,000 deaths and more than 21 million illnesses worldwide, including over 400,000 illnesses in Africa. The current study was conducted in four villages on Pemba Island, Zanzibar, in 2010. We present data on policy makers', health administrators', and village residents' and leaders' perceptions of typhoid fever, and hypothetical and actual health care use among village residents for typhoid fever. Qualitative data provided descriptions of home-based treatment practices and use of western pharmaceuticals, and actual healthcare use for culture-confirmed typhoid fever. Survey data indicate health facility use was associated with gender, education, residency, and perceptions of severity for symptoms associated with typhoid fever. Data have implications for education of policy makers and health administrators, design and implementation of surveillance studies, and community-based interventions to prevent disease outbreaks, decrease risks of complications, and provide information about disease recognition, diagnosis, and treatment.

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Section: Discussionmentioning

confidence: 99%

Utilization and Accessibility of Healthcare on Pemba Island, Tanzania: Implications for Health Outcomes and Disease Surveillance for Typhoid Fever

Kaljee

Pach²,

Thriemer³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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show abstract

“…Many vaccines using Salmonella mutants have failed due to either over-or underattenuation of the vaccine strain (29,58). Sadly, when strains that confer protection against typhoid were developed, economic pressures prevented the implementation of a vaccine program (6). Currently, translating the successes of clinical trials performed on the ⌬aroC/⌬ssaV mutant in healthy Western subjects to individuals in developing countries is a significant challenge (52).…”

Section: Vaccine Developmentmentioning

confidence: 99%

Salmonella : from Pathogenesis to Therapeutics

et al. 2007

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“…For instance, in the case of Shigella and oral cholera vaccines in Asia, uncertainty about the disease burden and high prices of the current vaccines and their moderate protection levels have inhibited their adoption. 92 Moreover, the cost of vaccine delivery in middle and low income countries should not be overlooked, as large new vaccines such as rotavirus can lead to bottlenecks that inhibit the delivery of other vaccines. [93][94][95] Evaluating the economics of vaccines for nearly all types of diarrheal diseases bring particular common challenges.…”

Section: Discussionmentioning

confidence: 99%