Polidocanol Concentration and Time Affect the Properties of Foam Used for Sclerotherapy

Abstract

Higher concentration of POL and rapid injection optimize foam stability and bubble size distribution, but other important foam characteristics are largely independent of differences in the generation and injection of foam. The authors have indicated no significant interest with commercial supporters.

Improvement of stability of polidocanol foam for nonsurgical permanent contraception

“…Strategies that optimize foam stability may make it possible to use of lower concentrations of polidocanol for nonsurgical permanent contraception. Although both 1% and 3% PF have been evaluated for venous sclerotherapy, no clinical benefit is seen with the higher concentration [3]. There is no clinical data on the safety of 5% PF so strategies that could improve the effectiveness of lower concentrations of polidocanol for use in permanent contraception should improve safety and acceptability of the approach.…”

“…Improving the stability of PF may increase polidocanol exposure time and PF delivery to the epithelial cells and thus allow use of lower concentrations for permanent contraception. A variety of approaches have been evaluated to improve foam stability for venous sclerotherapy; changing the foaming gas, adjusting polidocanol concentration, varying pH or temperature, adding chemicals and modifying the foaming device [2][3][4][5][6]. We explored two novel approaches to improve PF stability: (1) the effect of filter pore structure on foam formation (mechanical) and (2) the addition of a small amount of benzalkonium chloride (BZK) that has surfactant properties to stabilize bubbles (chemical).…”

Update of endovenous treatment modalities for insufficient saphenous veins—A review of literature

“…Also, different gases and methods of preparation are described 165 . The prepared foam is stable for about 2 minutes and therefore needs quick injection 166,167 . For UGFS of insufficient saphenous veins two different sclerosants can be used, including sotradecol (sodium tetradecyl sulphate) 1 and 3% and The amount of foam required for treatment of GSV insufficiency is usually 6-8 mL, depending on length and diameter of the vein 173 .…”

Die Sklerotherapie mit Luft- oder CO2-O2-Schaum

“…Polidocanol-Schaum ist bei höheren Konzentrationen stabiler (16,69), woraus wahrscheinlich eine gleichmäßigere Endothelschädigung resultiert. In dieser AWB fällt auf, das in beiden Gruppen mit höheren Polidocanol-Konzentrationen gearbeitet wurde, als in anderen Gruppen (27,28,56) Tab.…”