Polimiosite associada à arterite linfocítica do sistema nervoso central

Costa, Izaías Pereira da; Pradebon, Elisangela Possebon; Campos, Julia Villegas; Melo, Fabrícia Santos; Tavares, Flávia Midori Arakaki Ayres

doi:10.1590/s0482-50042010000100009

Cited by 2 publications

(1 citation statement)

References 14 publications

(22 reference statements)

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“…Criteria for PM/DM complicated with ILD: (1) the diagnosis met the international diagnostic criteria for PM/DM [7]; (2) diffuse ILD induced by other causes such as infections, heart failure and drug reaction were excluded; (3) patients have dry cough, progressive dyspnea, chest tightness and shortness of breath after activities and fine rales at the bases of double lungs; (4) chest CT (including high-resolution CT) revealed reticular changes in bilateral lungs, nodular exudation, frosted glass-like lesions, pulmonary consolidation, and honeycomb lungs; (5) pulmonary function examination revealed restrictive ventilatory dysfunction or diffuse dysfunction (lower than 80% of the expected value); (6) surgical lung biopsy revealed a result that met the ILD. Cases that met the first and second items plus any two of the other four items or the sixth item were diagnosed as DM complicated with ILD [8–10]. Patients with infectious pneumonia that improved after treatment with antibiotics were excluded.…”

Section: Methodsmentioning

confidence: 99%

Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance

Zhang

2019

Eur J Med Res

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Objective This study aims to detect serum levels of monocyte chemoattractant protein-1 (MPC-1) and transforming growth factor-β1 (TGF-β1) in polymyositis/dermatomyositis (PM/DM) patients complicated with interstitial lung disease (ILD), to reveal the significance of the changes in these levels in the pathogenesis of PM/DM complicated with ILD. Methods Serum MCP-1 and TGF-β1 levels in PM/DM patients complicated with ILD, patients with pulmonary infections and normal controls ( n = 30, each) were detected using enzyme-linked immunosorbent assay (ELISA), and the correlation between PM/DM complicated with ILD and serum MCP-1 and TGF-β1 levels was analyzed. Results Serum MCP-1 and TGF-β1 levels were both higher in PM/DM patients complicated with ILD compared with patients with pulmonary infections and normal controls. Conclusion Serum MCP-1 and TGF-β1 levels increased in PM/DM patients, and were closely correlated to the complication of ILD. This finding can be used for distinguishing between pulmonary infections and ILD, providing a new diagnostic method for the early prediction of DM/PM complicated with ILD.

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Section: Methodsmentioning

confidence: 99%

Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance

Zhang

2019

Eur J Med Res

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Fever, Myositis, and Paralysis: Is This Inflammatory Myopathy or Neuroinvasive Disease?

Kiran

Lau

et al. 2016

Case Reports in Rheumatology

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West Nile virus (WNV) is a mosquito-borne RNA Flavivirus which emerged in North America in 1999. Most patients present with a febrile illness but a few develop WNV neuroinvasive disease. Myopathy is an uncommon manifestation. We describe a case of a 42-year-old male from Los Angeles who presented with 8 days of fever and muscle pain. Initial physical exam was normal except for 4/5 muscle strength testing in his extremity proximal muscles. Laboratory revealed a creatine kinase of 45,000 and a urinalysis with large blood but no red blood cells, suggesting rhabdomyolysis. The patient's condition declined despite aggressive supportive care and hydration, and on hospital day #6 he developed severe altered mental status and progressed to complete right arm paralysis and 2/5 muscle strength in bilateral legs. EMG/NCS showed sensorimotor axonal polyneuropathy and the cerebrospinal fluid was positive for IgM and IgG WNV antibodies. The patient was diagnosed with WNV neuroinvasive disease, poliomyelitis (and encephalitis) type with myopathy/muscle involvement. He was treated supportively and his muscle and neurologic disease gradually improved. At 12-month follow-up his muscle enzymes had normalized and his weakness had improved to 5/5 strength in bilateral legs and 3/5 strength in the right arm.

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Polimiosite associada à arterite linfocítica do sistema nervoso central

Cited by 2 publications

References 14 publications

Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance

Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance

Fever, Myositis, and Paralysis: Is This Inflammatory Myopathy or Neuroinvasive Disease?

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