Polimorfismo corto del gen del transportador de la serotonina (5-httplr) y su asociación con la respuesta al estrés mediada por cortisol: un meta-análisis.

Agüero-Tejado, Emiliano

doi:10.6018/analesps.30.2.152921

Cited by 2 publications

(2 citation statements)

References 50 publications

(58 reference statements)

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“…Unfortunately, replication studies and several meta-analyses produced conflicting results [18,19], often attributed to false positives as a consequence of low statistical power [20]. Beyond depression, however, there is evidence that the 5-HTTLPR can also increase the affective responses to positive environment [21] and several more process-oriented meta-analyses indicate that the 5-HTTLPR plays a role in more basic physiological reactivity and affective functioning, even when publication bias is considered [22][23][24]. These robust effects corroborate that the 5-HTTLPR is a viable candidate to test competitive theories concerning the function of the serotonin system.…”

Section: Introductionmentioning

confidence: 99%

Highs and lows: Genetic susceptibility to daily events

et al. 2020

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Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person's reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susceptibility factor for daily events. Participants (N = 326, 77% female, mean age = 25, range = 17-36) completed smartphone questionnaires four times a day over four to five days, measuring stressors, uplifts, positive and negative affect. Affect was predicted from environment valence in the previous hour on a withinperson level using three-level autoregressive linear mixed models. The 5-HTTLPR fulfilled all criteria of a differential susceptibility factor: Positive affect in carriers of the short allele (S) was less reactive to both uplifts and stressors, compared to homozygous carriers of the long allele (L/L). This pattern might reflect relative affective inflexibility in S-allele carriers. Our study provides insight into the serotonin system's general role in susceptibility and highlights the need to assess the whole spectrum of naturalistic experiences.

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Section: Introductionmentioning

confidence: 99%

Highs and lows: Genetic susceptibility to daily events

et al. 2020

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“…Unfortunately, replication studies and several meta-analyses produced conflicting results (Bleys, Luyten, Soenens, & Claes, 2018;Culverhouse et al, 2018), often attributed to false positives as a consequence of low statistical power (Border et al, 2019). Beyond depression, however, there is converging evidence from more process-oriented meta-analyses which support that the 5-HTTLPR plays a role in more basic physiological reactivity and affective functioning, even when publication bias is considered (Agüero-tejado, 2014;Murphy et al, 2013;Pergamin-Hight, Bakermans-Kranenburg, van Ijzendoorn, & Bar-Haim, 2012). These robust effects corroborate that the 5-HTTLPR is a viable candidate to test competitive theories concerning the function of the serotonin system.…”

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confidence: 99%

Highs and Lows: Genetic Susceptibility to Daily Events

Sicorello¹,

Dieckmann²,

Moser³

et al. 2019

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Why people differ in their affective responses to external events is essential to ourunderstanding of personality, human development, and mental disorders. Genes explain asubstantial portion of these differences. Specifically, genes influencing the serotonin systemare hypothesized to be differential susceptibility factors, determining a person’s reactivity toboth positive and negative environments. We tested whether genetic variation in the serotonintransporter (5-HTTLPR, SLC6A4) is a differential susceptibility factor for daily events.Participants (N = 326) completed smartphone questionnaires four times a day over four to fivedays, measuring stressors, uplifts, positive and negative affect. Formal statistical criteria ofdifferential susceptibility were applied in a multilevel analysis framework. The 5-HTTLPRfulfilled all criteria of a differential susceptibility factor, marked by a disordinal geneenvironmentinteraction in the absence of both gene-environment correlation and direct geneticeffects on mood. Follow-up analyses revealed that positive affect in carriers of the short allele(S) was less contingent on both uplifts and stressors. Our study confirms the serotonin system’sgeneral role in susceptibility to immediate events and highlights the need to assess the wholespectrum of experiences.

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Polimorfismo corto del gen del transportador de la serotonina (5-httplr) y su asociación con la respuesta al estrés mediada por cortisol: un meta-análisis.

Cited by 2 publications

References 50 publications

Highs and lows: Genetic susceptibility to daily events

Highs and lows: Genetic susceptibility to daily events

Highs and Lows: Genetic Susceptibility to Daily Events

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