Polimorfismos del gen del receptor de vitamina D y riesgo de fractura de cadera en la mujer adulta mayor de la Región del Bío Bío

L, Iván Quevedo; B, Milka Martínez; N, Marcelo Castillo; F, Nancy Rivera

doi:10.4067/s0034-98872008000400008

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…Twenty-three studies were performed in Caucasians, and 9 studies [12,13,[47][48][49][50][51][52][53] were subsumed into Asians. In addition, 2 interracial studies [32,54] were conducted in mixed race. The main characteristics of the selected studies are listed in Table 1.…”

Section: Eligible Studiesmentioning

confidence: 99%

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

et al. 2020

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Objective This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results 4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians. Conclusion The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women.

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Section: Eligible Studiesmentioning

confidence: 99%

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

et al. 2020

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“…Por otro lado, un estudio publicado en el 2008, que incluyó a 126 mujeres chilenas, relacionó el riesgo de fractura de cadera en pacientes con polimorfismos del gen VDR, encontrando que Bsm I, Apa I, Taq I y Fok I se asocian a un mayor riesgo de fractura 59 . Además de este, otros artículos reportan la estrecha relación entre la densidad mineral ósea y los polimorfismos en el VDR, como es el caso del estudio mexicano dirigido por Jiménez-Salas Z y colaboradores, en el cual se midió la densidad mineral ósea de 150 mujeres y se determinó el genotipo del polimorfismo, concluyendo que el Taq l es el más relacionado con una pérdida acelerada de la densidad mineral ósea 60 .…”

Section: Polimorfismos Genéticos Asociados a Hipovitaminosis D Y Cierunclassified

Hipovitaminosis D: una visión desde la clínica y la biología molecular

Gallego-González

Mejía-Mesa

Martínez-Sánchez

et al. 2017

revmed

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ResumenLa vitamina D es una hormona que participa en gran cantidad de procesos fisiológicos y bioquímicos dentro del organismo humano, tales como la absorción de calcio y fosfato a nivel intestinal, regulación de la calcemia y mineralización ósea; además, tiene efectos sobre el ciclo celular, proliferación, diferenciación, señalización, apoptosis y producción de varias moléculas en diferentes células y tejidos, lo que explica la relación de sus bajos niveles con el desarrollo de múltiples patologías. En los últimos años, se ha reportado una elevada prevalencia de hipovitaminosis D a nivel mundial, que oscila entre el 50 y 92% según la población estudiada, producto de la deficiente exposición a la luz solar, escasa ingesta dietética, poco uso de suplementos vitamínicos, entre otros factores asociados. A su vez, se ha encontrado que la deficiencia de vitamina D es causada por algunos polimorfismos genéticos que afectan su metabolismo y conllevan al desarrollo de varias enfermedades. Debido a la importancia clínica de la vitamina D, se realizó esta revisión de la literatura por medio de la búsqueda de artículos originales, revisiones sistemáticas y narrativas en las bases de datos Pubmed y ScienceDirect y en el buscador Google Scholar. Se seleccionaron en total 71 artículos, a partir de los cuales se busca describir en el presente texto algunos de los aspectos relacionados con la fisiología, epidemiología, clínica y etiología de la hipovitaminosis D. Vitamin D deficiency: a view from clinical features and molecular biology AbstRActVitamin D is a hormone involved in many physiological and biochemical processes within the human, such as the absorption of calcium and phosphate in the intestine, regulation of blood calcium and bone mineralization; it also has effects on the cell cycle, proliferation, differentiation, signaling, apoptosis and production of various molecules in different cells and tissues, which explains the relationship between low levels of vitamin D and the development of many diseases. In recent years, there has been reported a high prevalence of vitamin D deficiency worldwide, ranging between 50 and 92% depending on the population studied, the result of poor exposure to sunlight, poor dietary intake, little use of vitamin supplements, among other associated factors. Hence, it has been found that vitamin D deficiency is caused by some genetic polymorphisms that affect their metabolism and lead to the development of various diseases. Because of the clinical importance of vitamin D, this review of the literature was conducted by the search for original articles, systematic reviews and narrative articles in PubMed, ScienceDirect and Google Scholar reviews. They were selected in total 71 articles, from which we seek to describe here some of the aspects of physiology, epidemiology, clinical and etiology of vitamin D deficiency. mÉD.uIs. 2017;30(1):45-56.

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“…For example, Garnero et al found that the VDR BsmI B allele was associated with lower BMD and an increased risk of fracture (Alvarez-Hernández et al, 2003). In contrast, other studies found no association between the B allele and the risk of osteoporotic fractures (Uitterlinden et al, 2001;Horst-Sikorska et al, 2005;Iván et al, 2008;Karpiński et al, 2017). Similarly, there were conflicting associations between the ApaI, TaqI, FokI, and Cdx2 polymorphisms and osteoporotic fractures in different studies (Gennari et al, 1999;Gómez et al, 1999;Garnero et al, 2005;Nguyen et al, 2005;Fang et al, 2006;Ji et al, 2010;Horst-Sikorska et al, 2013;Jawiarczyk-Przybyłowska et al, 2019;Iveta et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Association Studies and an Updated Meta-Analysis of VDR Polymorphisms in Osteoporotic Fracture Risk

Liu

Chen

et al. 2022

Front. Genet.

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Background: Several studies have examined the association between vitamin D receptor (VDR) polymorphisms and osteoporotic fracture risk; however, the results are not uniform. Furthermore, many new articles have been published, and therefore, an updated meta-analysis was performed to further explore these issues.Objectives: The aim of the study was to investigate the association between VDR, BsmI, ApaI, TaqI, FokI, and Cdx2 polymorphisms and osteoporotic fracture risk.Methods: The odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association between VDR BsmI, ApaI, TaqI, FokI, and Cdx2 polymorphisms and the risk of osteoporotic fracture. We also used the false-positive reporting probability (FPRP) test and the Venice criteria to evaluate the credibility of the statistically significant associations.Results: Overall, this study found that the VDR ApaI and BsmI polymorphisms significantly increased the risk of osteoporotic fracture in European countries and America, respectively. However, when sensitivity analysis was performed after excluding low-quality and Hardy–Weinberg disequilibrium (HWD) studies, it was found that only individuals with the double-mutated genotype have an increased risk of osteoporotic fracture in European countries. In addition, when the credibility of the positive results was assessed, it was found that the positive results were not credible.Conclusion: This meta-analysis indicates that there may be no significant association among the polymorphisms of VDR BsmI, ApaI, TaqI, FokI, and Cdx2 and the risk of osteoporotic fracture. The increased risk of osteoporotic fracture is most likely due to false-positive results.

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Polimorfismos del gen del receptor de vitamina D y riesgo de fractura de cadera en la mujer adulta mayor de la Región del Bío Bío

Abstract: Background: Osteoporotic hip fractures are devastating events in older women. There is a genetic modulation of bone phenotypic parameters including bone density (Rev Méd Chile 2008; 136: 475-81).

Cited by 11 publications

References 15 publications

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Hipovitaminosis D: una visión desde la clínica y la biología molecular

Evaluation of Association Studies and an Updated Meta-Analysis of VDR Polymorphisms in Osteoporotic Fracture Risk

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