Polimorfizm genov HLA klassa II i CTLA4 zdorovykh buryat i bol'nykh sakharnym diabetom 1 tipa v Buryatskoy Respublike

Дедов, И И; Колесникова, Л. И.; Иванова, О. Н.; Бардымова, Т. П.; Карлова, Н. Г.; Atamanova, T M; Prokof'ev, Sergey Alexandrovich

doi:10.14341/2072-0351-5373

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Since the locus of class II HLA belongs to the major ones that determine the genetic predisposition to DM1 (40-50% of inherited risk) one can expect the direct effect of the revealed peculiarities on the prevalence of DM1 and specifi city of its course in Buryat population [2].…”

Section: Resultsmentioning

confidence: 99%

“…Some studies reported low DM1 morbidity rate among the aboriginal people in Arctic and Siberian peoples resulted from the presence of the protective alleles for this nosology [4,10]. The prevalence of DM1 among aboriginal people in the Republic of Buryatia is 24.18 per 100,000, which is far below the average level in Russia (224.5 per 100,000) [2]. In etiology of DM1, the important role is played by genetic factors; specifi cally, the role of HLA genes attracts much attention.…”

Section: A Darenskayamentioning

confidence: 99%

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Lipid Status and Predisposing Genes in Patients with Diabetes Mellitus Type 1 from Various Ethnic Groups

et al. 2015

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The peculiarities of HLA class II profile and lipid metabolism were examined in Buryat and Russian ethnic groups of patients with diabetes mellitus type 1. The incidence of type 1 haplotypes in HLA class II gene family was lower in Buryats than that in Russians. In comparison with Russians, the course of diabetes mellitus type 1 in Buryat patients was characterized with a lower content of total lipids, triacylglycerols, total cholesterol, and LDL, which probably explains a more favorable course of the disease in Buryat population.

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Section: Resultsmentioning

confidence: 99%

Section: A Darenskayamentioning

confidence: 99%

Lipid Status and Predisposing Genes in Patients with Diabetes Mellitus Type 1 from Various Ethnic Groups

et al. 2015

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“…Популяционно специфическая генетическая архитектоника СД1 подтверждается работами, опу-бликованными ранее. Специфичны и спектр, и рас-пределение частот диабетогеннных аллелей, и сте-пень их ассоциации с СД1 [33][34][35][36].…”

Section: результаты и обсуждениеunclassified

Dimorphism -23HphI in the INS gene (rs689): the association with type 1 diabetes mellitus in the populations of the Russian Federation, the inter-population comparison of the frequencies

Ivanova

Stepanova

Smirnova

et al. 2014

Probl Endokrinol (Mosk)

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Objective. The objective of the present study was to elucidate the association between dimorfism -23HphI in the INS gene (rs689) and type 1 diabetes mellitus in several populations of the Russian Federation and to compare the frequency of alleles of this dimorphism in different populations. Material and methods. The case-control association was investigated in five populations of the Russian Federation, viz. Russian, Bashkir, Udmurtian, Yakutian, and Buryat ones. The DNA samples from 528 patients presenting with type 1 diabetes mellitus and 439 control subjects were available for the investigation, Polymorphism typing was performed using the RFLP-PCR technique. The degree of association of the trait of interest with the disease was estimated based on the odd ratio (OR) values. The calculations were made with the use of Statistica software package, version 6, www.statsoff.com and Microsoft Office Excel-2003. Results. The statistically significant association of type 1 diabetes mellitus with T allele and AA rs689 genotype was documented for the Russian, Bashkir, Udmurtian, and Yakutian populations. The protective marker in these populations were T allele and T+ genotype. A similar association was not found for the Buryat population characterized by the lowest diabetes morbidity rate. This population was significantly different from the remaining ones in the high frequency of A allele (87% vs 69-75%; p є [0.0002-0.004]) and AA genotype (77% vs 45-60%; p є [0.00006-0.01]). Conclusion. This study has demonstrated the inter-population differences in the frequency of rs689 alleles and the population-specific differences in the association of rs689 alleles with type 1 diabetes mellitus. It is concluded that the consideration of population-related peculiarities of clinical and genetic associations is an indispensable precondition for the further development of personalized medicine.

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Intensity of Oxidative Stress in Mongoloid and Caucasian Patients with Type 1 Diabetes Mellitus

et al. 2016

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Specific features of LPO were studied in Mongoloid and Caucasian patients with type 1 diabetes mellitus. The intensity of LPO in Mongoloid patients was lower than in Caucasians: the level of primary and intermediate products was by lower 1.53 and 1.83 times, while total antioxidant activity was elevated by 1.44 times, which was also supported by oxidative stress coefficient (1.35 in Mongoloids and 2.32 in Caucasians). These differences suggest that differentiated approach is required for the treatment of these patients.

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Polimorfizm genov HLA klassa II i CTLA4 zdorovykh buryat i bol'nykh sakharnym diabetom 1 tipa v Buryatskoy Respublike

Cited by 4 publications

References 16 publications

Lipid Status and Predisposing Genes in Patients with Diabetes Mellitus Type 1 from Various Ethnic Groups

Lipid Status and Predisposing Genes in Patients with Diabetes Mellitus Type 1 from Various Ethnic Groups

Dimorphism -23HphI in the INS gene (rs689): the association with type 1 diabetes mellitus in the populations of the Russian Federation, the inter-population comparison of the frequencies

Intensity of Oxidative Stress in Mongoloid and Caucasian Patients with Type 1 Diabetes Mellitus

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