Polimorfizm genów metaloproteinaz MMP-1 i MMP-2 w ocenie predyspozycji do zachorowania na raka krtani

Olejniczak, Izabela; Fendler, Wojciech; Borowiec, Maciej; Młynarski, Wojciech; Pietruszewska, Wioletta

doi:10.1016/s0030-6657(12)70782-5

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…[417][418] . ε δηάθνξεο έξεπλεο αζζελψλ -καξηχξσλ, έρεη απνδεηρζεί φηη νη θνξείο ηνπ αιιήιηνπ 2G πξνδηαζέηνληαη γηα δηάθνξνπο ηχπνπο θαξθίλσλ φπσο θαξθίλν καζηνχ [419][420][421] , σνζεθψλ [422][423] , ελδνκεηξίνπ, ηξαρήινπ ηεο κήηξαο [424][425][426] , παρένο εληέξνπ 411, 427-430 , λεθξψλ 431 , ξηλνθάξπγγα 414 , νπξνδφρνπ θχζηεο 412,432 , γιψζζαο 413 , ζηνκαηηθήο θνηιφηεηαο [433][434][435] , ιάξπγγα 436 , θαθφεζεο κειάλσκα 437 , ρνλδξνζάξθσκα [438][439] , αζηξνθχησκα 440 , πνιχκνξθν γινηνβιάζησκα [441][442] θαη αδέλσκα ππφθπζεο 443 . Ζ ζπζρέηηζε ηνπ πνιπκνξθηζκνχ κε ηνλ θαξθίλν ησλ πλεπκφλσλ έρεη αλαδεηρζεί ζε πνιιέο έξεπλεο [444][445][446][447][448] .…”

Section: θδραπδηαunclassified

Επίδραση των γονιδιακών πολυμορφισμών C242T, A640G και A930G στο γονίδιο της P22PHOX υπομονάδας της NADPH - οξειδάσης και του γονιδιακού πολυμορφισμού -1607 1G/2G στον υποκινητή του γονιδίου της MATRIX metalloproteinase 1 (MMP-1) στον κίνδυνο εκδήλωσης οστεοαρθρίτιδας γόνατος στο ελληνικό πληθυσμό

Lepetsos¹,

Λεπέτσος²

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Introduction. Osteoarthritis (OA) is the most common form of arthritis with still unknownpathogenic etiology and considerable contribution of genetic factors. Recently,a new emerging role of oxidative stress in the pathology of OA has beenreported, lacking however elucidation of the underlying mechanism.Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase being acomplex enzyme produced by chondrocytes, presents the major source ofreactive oxygen species (ROS) and main contributor of increased oxidativestress. One of the reasons of cartilage degradation in OA is enzymaticproteolysis of the extracellular matrix by metalloproteinases (MMPs). MMP-1,produced by chondrocytes and synovial cells, is a major proteinase of theMMPs family. The present study aims to evaluate the association of NADPHoxidase p22phox gene C242T, A640G and -A930G polymorphisms andMMP1 gene -1607 1G/2G polymorphism with primary knee OA in the Greekpopulation.Materials and MethodsOne hundred fifty five patients with primary symptomatic knee OA participatedin the study along with 139 matched controls. Genotypes were determinedusing polymerase chain reaction and restriction fragment lengthpolymorphism (PCR - RLFP) technique. Allelic and genotypic frequencieswere compared between both study groups.ResultsNo significant difference was detected for NADPH p22phox C242T andA640G polymorphisms (P>0.05). –A930G polymorphism was significantly associated with knee OA in the crude analysis (P= 0.018). The associationbetween –A930G polymorphism and knee OA disappeared when the resultswere adjusted for obesity (P= 0.078, OR: 0.54, 95%CI: 0.272-1.071). Therewas no significant association between MMP1 -1607 1G/2G polymorphismand knee OA, in crude analysis; however after multiple logistic regressionanalysis, 1G/2G was associated with reduced odds of knee OA by 75% inmales, compared to genotypes 1G/1G+2G/2G, adjusting for age and BMI(adjusted OR: 0.25, 95% CI: 0.069, 0.910, p-value=0.035). The interactionbetween all four polymorphisms was not significant.ConclusionsThe present study shows that NADPH oxidase p22phox gene C242T andA640G are not risk factors for knee OA susceptibility in the Greek population.–A930G and MMP1 -1607 1G/2G polymorphisms might contribute to knee OApathogenesis. Further studies are needed to give a global view of theimportance of this polymorphisms in the pathogenesis of OA.

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Section: θδραπδηαunclassified

Επίδραση των γονιδιακών πολυμορφισμών C242T, A640G και A930G στο γονίδιο της P22PHOX υπομονάδας της NADPH - οξειδάσης και του γονιδιακού πολυμορφισμού -1607 1G/2G στον υποκινητή του γονιδίου της MATRIX metalloproteinase 1 (MMP-1) στον κίνδυνο εκδήλωσης οστεοαρθρίτιδας γόνατος στο ελληνικό πληθυσμό

Lepetsos¹,

Λεπέτσος²

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Matrix metalloproteinase-2 (MMP-2) gene polymorphism and cardiovascular comorbidity in type 2 diabetes patients

Buraczyńska¹,

Drăgan²,

Buraczynska³

et al. 2015

Journal of Diabetes and its Complications

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Mechanism of Astragalus membranaceus in the treatment of laryngeal cancer based on gene co-expression network and molecular docking

Dong

Huo

Sun

et al. 2020

Sci Rep

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Astragalus membranaceus (HUANG QI, HQ) is a kind of traditional Chinese medicine. Researchers have widely concerned its antitumor effect. At present, there is still a lack of research on the treatment of laryngeal cancer with HQ. In this study, we integrated data from the weighted gene co-expression network of laryngeal cancer samples and the components and targets of HQ. A new method for dividing PPI network modules is proposed. Important targets of HQ treatment for laryngeal cancer were obtained through the screening of critical modules. These nodes performed differential expression analysis and survival analysis through external data sets. GSEA enrichment analysis reveals pathways for important targets participation. Finally, molecular docking screened active ingredients in HQ that could interact with important targets. Combined with the laryngeal cancer gene co expression network and HQ PPI network, we obtained the critical module related to laryngeal cancer. Among them, MMP1, MMP3, and MMP10 were chosen as important targets. External data sets demonstrate that their expression in tumor samples is significantly higher than in normal samples. The survival time of patients with high expression group was significantly shortened, which is a negative factor for prognosis. GSEA enrichment analysis found that they are mainly involved in tumor-related pathways such as ECM receptor interaction and Small cell lung cancer. The docking results show that the components that can well bind to important targets of HQ are quercetin, rutin, and Chlorogenic acid, which may be the primary mechanism of the anti-cancer effect of HQ. These findings provide a preliminary research basis for Chinese medicine treatment of laryngeal cancer and offer ideas to related drug design. Laryngeal cancer is one of the common malignant tumors of the head and neck, most of which are squamous cell carcinoma 1. It ranks second in the incidence of head and neck cancer (HNSC). The affected population is mainly middle-aged and older men over 40 years old, with a slight trend of youth 2. The occurrence and development of laryngeal cancer are related to many factors, including smoking, drinking, HPV infection, radiation, low intake of vegetables and fruits, insufficient trace elements, and disorders of sex hormone metabolism 3-5. In the early stage of laryngeal cancer, laser treatment has less damage and less postoperative complications 6. For most patients with laryngeal cancer, open surgery is still the main treatment. Radiotherapy and chemotherapy were used as auxiliary means 7. Targeted treatment of tumor can increase drug sensitivity, improve curative effect and reduce side effects 8. However, not all patients can benefit from it 9. Clearing tumors, preserving function, controlling recurrence, and improving quality of life are the goals of treating laryngeal cancer 5 .

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Polimorfizm genów metaloproteinaz MMP-1 i MMP-2 w ocenie predyspozycji do zachorowania na raka krtani

Cited by 3 publications

References 20 publications

Matrix metalloproteinase-2 (MMP-2) gene polymorphism and cardiovascular comorbidity in type 2 diabetes patients

Mechanism of Astragalus membranaceus in the treatment of laryngeal cancer based on gene co-expression network and molecular docking

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