Poliovirus vaccine-inactivated

Plotkin, Stanley А.; Vidor, Emmanuel

doi:10.1016/b978-1-4160-3611-1.50029-5

Cited by 37 publications

(62 citation statements)

References 151 publications

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“…However, a serum neutralizing antibody titer of 1:8 is considered to be a level of effective antibody protection againsted poliovirus. 29 It should be point out that the first dose of fractional-dose of sIPV in the ID groups only stimulated lower seroconversion than IM group with one-full dose. But, the rates of seroconversion could increase faster after the second dose in the ID group.…”

Section: Discussionmentioning

confidence: 83%

Analyzed immunogenicity of fractional doses of Sabin-inactivated poliovirus vaccine (sIPV) with intradermal delivery in rats

Cai

Sun

Cun

et al. 2016

Human Vaccines & Immunotherapeutics

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The live-attenuated oral polio vaccine (OPV) will be no longer used when wild poliovirus (WPV) eliminating in worldwide, according to GPEI (the Global Polio Eradication Initiative) Reports. It is planning to replace OPV by Sabin-based inactivated poliovirus vaccine (sIPV) in developing countries, with purpose of reducing of the economic burden and maintaining of the appropriate antibody levels in population. It studied serial fractional doses immunized by intradermal injection (ID) in rats, to reduce consume of antigen and financial burden, maintaining sufficient immunogenicity; Methods: Study groups were divided in 4 groups of dose gradient, which were one-tenth (1/10), one-fifth (1/5), one-third (1/3) and one-full dose (1/1), according to the volume of distribution taken from the same batch of vaccine (sIPV). Wistar rats were injected intradermally with the needle and syringe sing the mantoux technique taken once month for 3 times. It was used as positive control that intramuscular inoculation (IM) was injected with one-full dose (1/1) with same batch of sIPV. PBS was used as negative control. Blood samples were collected via tail vein. After 30 d with 3 round of immunization, it analyzed the changes of neutralization antibody titers in the each group by each immunization program end; Results: The results of seroconversion had positive correlation with different doses in ID groups. The higher concentration of D-antigen (D-Ag) could conduct higher seroconversion. Furthermore, different types of viruses had different seroconversion trend. It showed that the geometric mean titers (GMTs) of each fractional-dose ID groups increased by higher concentration of D-Ag, and it got significant lower than the full-dose IM group. At 90 days of immunization, the GMTs for each poliovirus subtypes of fractional doses were almost higher than 1:8, implied that it could be meaning positive seroprotection titer for polio vaccine types, according to WHO suggestion; Conclusions: The fractional dose with one-fifth (1/5) could be used by intradermal injection to prevent poliovirus infection, if there were more human clinical detail research consistent with this findings in rats.

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Section: Discussionmentioning

confidence: 83%

Analyzed immunogenicity of fractional doses of Sabin-inactivated poliovirus vaccine (sIPV) with intradermal delivery in rats

Cai

Sun

Cun

et al. 2016

Human Vaccines & Immunotherapeutics

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“…diendo la sIgA en las secreciones nasofaringeas y en el intestino. La detección de sIgA específica frente al poliovirus en intestino se ha correlacionado con una reducción de virus excretado 22,23 . La OPV induce anticuerpos neutralizantes en la nasofaringe en más de un 70% de receptores de la vacuna 24 .…”

Section: Figura 4 Fotografía De Jonas Salkunclassified

Análisis de la influencia de los cambios en las características sociodemográficas en la erradicación de la poliomielitis en Nigeria

Sánchez¹

2015

Ene.

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“…Des études ont montré que plus de 89 à 100 % des nourrissons ayant reçu le VPI selon un calendrier à deux doses (à l'âge de 2 et 4 mois) et de 93 à 100 % des nourrissons ayant reçu le vaccin selon un calendrier à trois doses (à l'âge de 2, 3 et 4 mois) ont développé des anticorps séroprotecteurs un mois après l'administration de la dernière dose. À titre de comparaison, le taux de séroprotection est de près de 100 % selon un calendrier d'administration du vaccin à 2, 4, 6 mois et entre 12 et 18 mois (12).…”

Section: Immunogénicité Et Innocuité Du Vaccinunclassified

Déclaration concernant le poliovirus et les voyageurs internationaux du Comité consultatif de la médecine tropicale et de la médecine des voyages (CCMTMV)

2014

RMTC

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Poliovirus vaccine-inactivated

Cited by 37 publications

References 151 publications

Analyzed immunogenicity of fractional doses of Sabin-inactivated poliovirus vaccine (sIPV) with intradermal delivery in rats

Analyzed immunogenicity of fractional doses of Sabin-inactivated poliovirus vaccine (sIPV) with intradermal delivery in rats

Análisis de la influencia de los cambios en las características sociodemográficas en la erradicación de la poliomielitis en Nigeria

Déclaration concernant le poliovirus et les voyageurs internationaux du Comité consultatif de la médecine tropicale et de la médecine des voyages (CCMTMV)

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