Poliposis gástrica secundaria a tratamiento con inhibidores de la bomba de protones

Huguet, José María; Ruiz, Lucía; Ortí, E; Luján, M; Sempere, Javier; Medina, Enrique

doi:10.1016/j.gastrohep.2008.09.008

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…All efforts should be done to rule out neoplastic lesion in a polypoid gastric lesion and a careful follow up seems mandatory. We documented regression of these polyps following stoppage of PPI therapy like in other studies [8]. Long term of PPI usage is difficult to define.…”

Section: Discussionsupporting

confidence: 68%

A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy

Alqutub

Masoodi²

2010

GMS German Medical Science; 8:Doc19; ISSN 1612-3174

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Section: Discussionsupporting

confidence: 68%

A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy

Alqutub

Masoodi²

2010

GMS German Medical Science; 8:Doc19; ISSN 1612-3174

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“…Este achado foi maior que alguns relatos de literatura onde a prevalência variou entre 1,9% 10 e 5,2% 14 e foi menor que 16,3% 12 , prevalência encontrada em estudo brasileiro. Esses foram encontrados em mucosa de fundo e corpo, poupando a mucosa antral, seguindo os relatos de estudos prévios 8,12 . Não houve achado de displasia nos pólipos encontrados neste grupo.…”

Section: Discussionunclassified

“…Estudos recentes têm postulado a relação entre o uso crônico destas drogas com alterações proliferativas da mucosa do fundo e corpo gástrico 2,3,6,8,10 . Controvérsias quanto a esta relação existem e já foram descritas em grandes estudos onde não houve diferença estatística entres os grupos.…”

Section: Introductionunclassified

Prevalência de alterações proliferativas gástricas em pacientes com uso crônico de inibidores de bomba de prótons

Menegassi

Czeczko

et al. 2010

ABCD, arq. bras. cir. dig.

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DESCRITORES -Inibidores da bomba de prótons. Mucosa gástrica. Pólipos. ABSTRACT -Background -The medications most often prescribed and used chronically by patients with dyspeptic symptoms belong to the group of inhibitors of proton pump whose main representative is omeprazole, used clinically about 20 years. Recent studies have postulated the relationship between chronic use of this medication and macroscopic and microscopic proliferative changes in mucosal of gastric body, especially the fundic gland polyps. Aim -To analyze the frequency and type of gastric proliferative changes in chronic users of proton pump inhibitors proton and its association with age, dose, time of use, symptoms and Helicobacter pylori infection. Methods -A survey of prevalence was conducted in Digestive Endoscopy Service, Hospital de Clínicas, Federal University of Paraná, using questionnaire referring the use of these drugs and performed in subjects using this class of drugs during at least 12 months prior to the endoscopy. Gastric biopsies of fundus, body and antrum were performed in all patients. Polyps were removed when present for histopathological analysis. Research on Helicobacter pylori was done by urease test and histopathology. RESUMO -RacionalResults -Twenty-two individuals were included of which six (27.3%) had proliferative changes of the mucosa. Of these, two (9.1%) had sporadic fundic polyps and four only microscopic proliferative change as cystic glandular formation. Statistic significant (p <0.05) association between age ≥ 60 years and these changes was found. There was no association between dose of use, time of use, symptoms and Helicobacter pylori infection. Conclusions -It was observed the existence of proliferative mucosa changes in individuals with chronic use of inhibitors of proton pump. In this group, the association between age and proliferative changes was significant.

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Poliposis gástrica secundaria a tratamiento con inhibidores de la bomba de protones

Cited by 2 publications

References 13 publications

A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy

A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy

Prevalência de alterações proliferativas gástricas em pacientes com uso crônico de inibidores de bomba de prótons

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