Polish Society of Gynecologists and Obstetricians recommendation on the use of antiseptics for treatment of inflammatory vaginitis

Zimmer, Mariusz; Huras, Hubert; Kamiński, Paweł; Karowicz-Bilińska, Agata; Drews, Krzysztof; Fuchs, Tomasz; Pomorski, Michał

doi:10.5603/gp.2020.0104

Cited by 5 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In gynecology, the use of PHMB in the treatment of inflammatory and dysbiotic diseases of the vagina has been determined since it does not have an inhibitory effect on the growth of Lactobacillus spp. and does not have strong toxicity or allergenicity when used vaginally [ 54 , 55 ]. Polyhexanide is mentioned in the literature for the treatment of acanthamoebic keratitis [ 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

et al. 2023

View full text Add to dashboard Cite

Background:chronic apical periodontitis is a common pathology in dentistry, especially in endodontics. It is necessary to systematize data concerning commonly used irrigation solutions. The development of new protocols for endodontic treatment is a very promising direction. The use of a polyhexanide-based antiseptic can positively affect the results of endodontic treatment. Methods: the review was carried out involving the search for English language research and meta-analyses in the Google Scholar and PubMed databases. Results: the number of literary sources that were identified during the literature review is 180. After excluding publications that did not match the search criteria, the total number of articles included in the systematic review was determined to be 68. Conclusions: polyhexanide is a promising solution for infected root canal irrigation. The antibacterial activity of this substance is suitable for the elimination of pathogens responsible for the appearance of apical periodontitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Dequalinium chloride is recommended by several international and European guidelines as alternative treatment for BV or inflammatory vaginitis. 8,10,11,[31][32][33] Dequalinium chloride adsorbs into the cell surface, altering its permeability; disrupts protein synthesis; and induces protein denaturation and precipitation of nucleic acids. 25 Due to these multiple modes of action, the development of resistance is unlikely.…”

Section: Introductionmentioning

confidence: 99%

“…Several clinical studies have reported the efficacy and safety of dequalinium chloride against vaginal infections. Dequalinium chloride is recommended by several international and European guidelines as alternative treatment for BV or inflammatory vaginitis . Dequalinium chloride adsorbs into the cell surface, altering its permeability; disrupts protein synthesis; and induces protein denaturation and precipitation of nucleic acids .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Dequalinium Chloride vs Metronidazole for the Treatment of Bacterial Vaginosis

Raba,

Ďurkech,

Malík

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceBacterial vaginosis (BV) is a common cause of vaginal infection. First-line treatments of BV are metronidazole and clindamycin. Due to the increase in antibiotic resistance, effective nonantibiotic treatments for BV are needed.ObjectiveTo examine whether dequalinium chloride, a broad-spectrum antiseptic, is noninferior to oral metronidazole for the treatment of BV.Design, Setting, and ParticipantsThis phase 4, multicenter, triple-blind, double-dummy, parallel, noninferiority randomized clinical trial was conducted from July 29, 2021, to August 25, 2022, with a 1-month follow-up. Participants were premenopausal women 18 years or older with BV from 11 gynecologic practices and 1 hospital in Poland, Slovakia, and the Czech.InterventionPatients were randomized to treatment with dequalinium chloride vaginal tablets (10 mg once daily for 6 days) or oral metronidazole (500 mg twice daily for 7 days). Double-dummy medication kits contained vaginal and oral tablets with placebo and active medication.Main Outcomes and MeasuresThe main outcome was the noninferiority margin (of 15 percentage points) in the absolute difference in clinical cure rates between dequalinium chloride and metronidazole 7 to 11 days after start of treatment (visit 1). Noninferiority was met if the lower 95% CI for the difference in clinical cure rate was less than 15 percentage points at visit 1.ResultsA total of 147 women (mean [SD] age, 36.7 [9.0] years) were treated with dequalinium chloride (n = 72) or metronidazole (n = 75). The clinical cure rates at visit 1 were 64 of 69 (92.8%) for dequalinium chloride vs 69 of 74 (93.2%) for metronidazole in the intention-to-treat population, whereas in the per-protocol population, cure rates were 54 of 58 (93.1%) for dequalinium chloride vs 48 of 53 (90.6%) for metronidazole. The treatment differences of −0.5 percentage points (95% CI, −10.8 to 9.8 percentage points; P = .002) in the intention-to-treat population and 2.5 percentage points (95% CI, −9.4 to 14.4 percentage points; P = .001) in the per-protocol population confirmed the noninferiority of dequalinium chloride. The tolerability of dequalinium chloride was rated as very good by 30 of 50 patients (60.0%) but only by 21 of 54 (38.9%) for metronidazole. Three patients in the metronidazole group suspended treatment due to an adverse event.Conclusions and RelevanceThis randomized clinical trial showed that dequalinium chloride was not inferior to metronidazole for the treatment of BV. Dequalinium chloride had a similarly high cure rate but with better tolerability and fewer adverse events. With a similar efficacy to metronidazole and clindamycin, dequalinium chloride warrants consideration as first-line treatment for BV to help reduce antibiotic consumption.Trial RegistrationEudraCT: 2020-002489-15

show abstract

Treatment of nonspecific vulvovaginitis in pregnant women: evaluation of the effectiveness of two-stage therapy

Shaposhnikova,

Majidli

2024

Rus. J. Hum. Repro.

View full text Add to dashboard Cite

Polish Society of Gynecologists and Obstetricians recommendation on the use of antiseptics for treatment of inflammatory vaginitis

Cited by 5 publications

References 35 publications

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment

Efficacy of Dequalinium Chloride vs Metronidazole for the Treatment of Bacterial Vaginosis

Treatment of nonspecific vulvovaginitis in pregnant women: evaluation of the effectiveness of two-stage therapy

Contact Info

Product

Resources

About