Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome

Abstract

The therapeutic efficacy for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is currently unsatisfactory. The aim of the present study was to assess the safety and efficacy of pollen extract in association with vitamins (DEPROX 500®) in males with CP/CPPS. All patients with a diagnosis of CP/CPPS attending the same urologic centre between March and October 2012 were enrolled in this randomised controlled phase III study. Participants were randomised to receive oral capsules of DEPROX 500® (two capsules every 24 h) or ibuprofen (600 mg, one tablet three times a day) for four weeks. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score and Quality of Well-Being (QoL) questionnaires were used. In the intention-to-treat analysis, 87 males (25 class IIIa and 62 class IIIb) with a mean age of 33.6±5.9 years were randomly allocated to the DEPROX 500® (n=41) or ibuprofen (n=46) treatment groups. At the follow-up examination (following one month of treatment), in the DEPROX 500® group, 31/41 patients (75.6%) reported an improvement in quality of life, defined as a reduction of the NIH-CPSI total score by ≥25%, compared with 19/46 (41.3%) in the control group (P=0.002). The greater improvement in the DEPROX 500® group compared with the ibuprofen group was statistically significant (treatment difference in the NIH-CPSI pain domain, −2.14±0.51, P<0.001; QoL scores, P=0.002). All patients were negative at the Meares-Stamey test evaluation. Adverse events were less frequent in the DEPROX 500® group than in the ibuprofen group. The DEPROX 500® treatment significantly improved total symptoms, pain and quality of life compared with ibuprofen in patients with CP/CPPS, without severe side-effects.

The Clinical Efficacy of Pollen Extract and Vitamins on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Is Linked to a Decrease in the Pro-Inflammatory Cytokine Interleukin-8

“…The inclusion criteria were the presence of pelvic pain symptoms for at least 3 months during the 6 months before study enrolment in accordance with the European Association of Urology guidelines, a score in the pain domain of the NIH-CPSI of >4 and a negative result for the Meares-Stamey 4-glass test [ 11 15 16 ]. We excluded all patients with the following characteristics: subjects <18 and >65 years of age affected by major concomitant diseases with known anatomical abnormalities of the urinary tract or with evidence of other urological diseases with residual urine volume >50 mL resulting from bladder outlet obstruction, subjects with a reported allergy to pollen extract who had recently (within <4 weeks) undergone oral or parental treatment or who were currently using prophylactic antibiotic drugs, and all patients who tested positive for Chlamydia trachomatis , Ureaplasma urealyticum , Neisseria gonorrhoeae , herpesviruses (HSV 1/2), and human papillomavirus (HPV).…”

Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits

“…Participants were randomised to receive oral capsules of DEPROX 500 ® (two capsules/day; n = 41) or ibuprofen (600 mg, one tablet three times/day; n = 46) for four weeks ↓ NIH-CPSI total score by ≥ 25% ↓ Adverse events in the DEPROX 500 ® treatment group compared to ibuprofen ↑ pain relief and QoL in DEPROX 500 ® treatment group ↑ antioxidant activity of the pollen extract and protective effect on nerves by vitamins combination [159] Note: BPH-Benign Prostatic Hyperplasia; LEPS-leukocytes in expressed prostatic secretion; MDA-malondialdehyde; NIH-CPSI-The National Institutes of Health Chronic Prostatitis Symptom Index; NIH-National Institutes of Health; NO-nitric oxide; QoL-Quality of Well-Being; SOD-superoxide dismutase; WBC-white blood cell count; ↓-decrease; ↑-increase.…”

Proteomic Analysis of Pollen and Blossom Honey from Rape Seed Brassica Napus L.

“…It was also important whether pollen was gathered by hand directly from the flower or by bees which is particularly rich in vitamins with a far higher concentration of pantothenic acid. The German Federal Board of Health has officially recognized the use of pollen as medicine; pollen has been helpful when administered in cases of chronic prostatitis (Cai et al, 2014;Wagenlehner et al, 2009). Some chronic diseases such as cancer, coronary, and neurological degeneration have been reported to be a consequence of oxidative damage (Babizhayev, Vishnyakova, & Yegorov, 2014;Jiang, Sun, & Chen, 2016).…”