Pollen Food Allergy Syndrome in Allergic March

Abstract

The association between pollen food allergy syndrome (PFAS) and allergic march remains unclear. In this prospective cohort study of the general population in Tokyo (T-Child Study), we found that sensitization to Cry j 1 and Fel d 1 at ages 5 and 9 years was associated with an increased risk of PFAS at 13 years old (at 5 years, Cry j 1: adjusted odds ratio aOR, 2.74; 95% confidence interval CI, 1.53–4.91; Fel d 1: aOR, 2.61; 95% CI, 1.31–5.19; at 9 years, Cry j 1: adjusted odds ratio aOR, 4.28; 95% confidence interval CI, 1.98–9.25; Fel d 1: aOR, 2.40; 95% CI, 1.33–4.32). In particular, sensitization to Bet v 1 at ages 5 and 9 years was associated with a strong risk of PFAS at the age of 13 years (at 5 years: aOR, 10.6; 95% CI, 2.64–42.5; at 9 years: aOR, 9.1; 95% CI, 4.71–17.6). PFAS risk by age 13 years was increased by any allergic symptom at 5 or 9 years, a combination of wheezing, eczema, and rhinitis, and Bet v 1 sensitization. Our findings suggest that PFAS may be associated with allergic march.

Carrot-Induced Systemic Reaction: A Unique Presentation of Pollen-Food Allergy Syndrome in a Young Boy

“…We hypothesize that the severity of PFAS symptoms correlates with the concentration of birch pollen in the air, with these symptoms aggravating during the pollen season and shortly afterward [10]. In an article by Yasudo et al, it is proposed that PFAS could potentially be a part of the allergic march [17]. The study found that at the age of five, IgE sensitization to Bet v1 was observed in 2.2% of participants, and this percentage increased to 13.9% by the age of nine.…”

“…This increase in IgE level was identified as a risk factor for PFAS in adolescence. It is plausible that the boy is experiencing this phenomenon, progressing from pollinosis to a unique systemic reaction, as a manifestation of PFAS [17]. The patient reports allergy symptoms to peaches and plums, for which he has no sIgE detected.…”

The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults

“…PFAS/OAS can present in childhood, adolescence, or adulthood with prevalence rates ranging from 4.7 to over 20% in children and from 13 to 58% in adults, suggesting increased development over a lifetime and that PFAS/OAS may often be persistent [ 92 ]. Yasudo et al found that childhood symptoms of wheeze, eczema, or allergic rhinitis at age 5 or 9 were risk factors for the development of PFAS/OAS by age 13 years [ 93 ].…”