Pollen morphology of Croton of the New World and pollen evolution of tribe Crotoneae (Euphorbiaceae)

Souza, Lidian R. de; Silva, Otávio Luis Marques da; Santos, Francisco de Assis Ribeiro dos; Carneiro‐Torres, Daniela Santos

doi:10.1016/j.revpalbo.2020.104279

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Within this, the Euphorbiaceae family stands out for having compounds with therapeutic properties, which can be extracted for use in medicine (Amorzo, 2002). One of the genera of Euphorbiaceae is Croton, which has about 1,200 species worldwide (Souza et al, 2020). This genus presents phenolic compounds, such as flavonoids, lignoids and protoanthocyanidins (Salatino et al, 2007), besides being abundant in several classes of alkaloids (Torres, 2008) and secondary metabolites, mainly clerodan diterpenes (Salatino et al, 2007), which are bicyclic diterpenes known for their biological activities, such as anticancer, anti-inflammatory and antioxidants (Alencar et al, 2017;Neri et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of extracts and compounds isolated from Croton echioides in animal tumor cell (HTC)

et al. 2022

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The search for compounds with anticancer effects is of paramount importance today due to the high incidence of the disease. The Euphorbiaceae family is known for having compounds with therapeutic properties, one of its genera being Croton. It has several species, which contain compounds already known for their biological activities, presenting anti-inflammatory, antimicrobial and anticancer properties. Thus, the cytotoxicity/antiproliferative activity of semi-purified fractions and compounds isolated from Croton echioides in liver tumor cells of Rattus norvegicus (HTC) was evaluated by the MTT test. The semi-purified fractions showed cytotoxicity at concentrations above 200 µg/mL, at 24, 48 and 72 hours, reaching cell viability of 24.78% [400 µg/mL] at 24 hours, 12.79% [500 µg/mL] at 48 hours and 10.57% [300 µg/mL] at 72 hours. For the isolated compounds, lupeol had a cytotoxic effect in all concentrations (1, 5, 10, 15, 20, 40, 60, 80 and 100 µg/mL) and tested times (24, 48 and 72 hours), reaching minimum viability of 4.37% [100 µg/mL], within 72 hours. The clerodan diterpenes CEH-1 and CEH-4 also showed antiproliferative activity, with minimum viability of 36.19% [100 µg/mL] over 72 hours and 21.33% [100 µg/mL] over 48 hours, respectively. However, the clerodan diterpenes CEH-2 and CEH-3 did not shows a cytotoxic effect for HTC cells. Thus, there is a cytotoxic/antiproliferative potential of C. echioides against tumor cells, with targeted to mitochondrial enzymes, associated with cell proliferation, indicating that this species deserves prominence in the search for new molecules for the treatment of cancer.

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