Pollen respiratory allergy: Is it really seasonal?

D’Amato, Gennaro; Murrieta‐Aguttes, Margarita; D’Amato, Maria; Ansotegui, Ignacio J.

doi:10.1016/j.waojou.2023.100799

Cited by 15 publications

(3 citation statements)

References 57 publications

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“…Approximately 20–30% of adults and up to 40% of children worldwide suffer from allergic diseases, and allergies to inhalant allergens such as birch pollen (BP) are increasing in the northern hemisphere ( 1 ). Allergic immune reactions are characterized by the induction of a type 2 response including Th2 cell differentiation, secretion of the major cytokine IL-4 and release of the antibody subtype IgE.…”

Section: Introductionmentioning

confidence: 99%

NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization

Bauer,

Dang,

Neureiter

et al. 2024

Front. Immunol.

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Introduction & ObjectiveAllergic sensitization is an essential step in the development of allergic airway inflammation to birch pollen (BP); however, this process remains to be fully elucidated. Recent scientific advances have highlighted the importance of the allergen context. In this regard, microbial patterns (PAMPs) present on BP have attracted increasing interest. As these PAMPs are recognized by specialized pattern recognition receptors (PRRs), this study aims at investigating the roles of intracellular PRRs and the inflammasome regulator NLRP3.MethodsWe established a physiologically relevant intranasal and adjuvant-free sensitization procedure to study BP-induced systemic and local lung inflammation.ResultsStrikingly, BP-sensitized Nlrp3-deficient mice showed significantly lower IgE levels, Th2-associated cytokines, cell infiltration into the lung, mucin production and epithelial thickening than their wild-type counterparts, which appears to be independent of inflammasome formation. Intriguingly, bone-marrow chimera revealed that expression of NLRP3 in the hematopoietic system is required to trigger an allergic response.ConclusionOverall, this study identifies NLRP3 as an important driver of BP-induced allergic immune responses.

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Section: Introductionmentioning

confidence: 99%

NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization

Bauer,

Dang,

Neureiter

et al. 2024

Front. Immunol.

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“…In recent years, the number of individuals with allergies has increased in both developed and developing countries [ 1 ]. Sufferers of allergic rhinitis, an allergic reaction to pollen and molds, among others, fall into this category [ 2 ]. Pollen allergy is a typical type I allergic disease associated with respiratory sensitization to an inhaled antigen wherein pollen from certain plants that are otherwise harmless to humans are recognized as antigens, triggering allergic responses.…”

Section: Introductionmentioning

confidence: 99%

Anti-allergic effect of <i>Cyclopia</i> (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen

SHIMBO,

FUKAGAWA,

NAKAMURA

et al. 2024

Bioscience of Microbiota, Food and Health

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The anti-allergic effects of extracts prepared from two species of honeybush, Cyclopia genistoides and C. subternata, were demonstrated in vivo in a murine allergy model for inhaled antigen induced with ovalbumin (OVA) inhalation to mimic pollen allergy. Intake of the extracts increased the production of OVA-specific immunoglobulin (Ig) E (IgE), IgG1, and IgG2a antibodies in serum and significantly suppressed anaphylactic reactioninduced body temperature decline. Moreover, the extracts significantly inhibited antigenantibody-induced degranulation in RBL-2H3 cells. They also inhibited body temperature decline when the allergic mice were given them after antigen sensitization, indicating that anti-degranulation activity is the major mechanism underlying the anti-allergic effect of Cyclopia extracts. Despite their qualitative and quantitative differences in phenolic composition, the two extracts exhibited similar effects, suggesting that several active compounds might be involved in the activity. Therefore, oral administration of either Cyclopia extract potentially exerts a systemic anti-allergic effect, supporting the increased consumption of honeybush tea for general wellness and improved quality of life.

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“…Approximately 20-30% of adults and up to 40% of children worldwide suffer from allergic diseases, and allergies to inhalant allergens such as birch pollen (BP) are increasing in the northern hemisphere (1). Allergic immune reactions are characterized by the induction of a type 2 response including Th2 cell differentiation, secretion of the major cytokine IL-4 and release of the antibody subtype IgE.…”

Section: Introductionmentioning

confidence: 99%

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Pollen respiratory allergy: Is it really seasonal?

Cited by 15 publications

References 57 publications

NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization

NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization

Anti-allergic effect of <i>Cyclopia</i> (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen

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