Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment

Yang, Qingxin; Tang, Songsong; Lu, Dongdong; Li, Yangyang; Wan, Fangchen; Li, Jiahong; Chen, Qiwei; Cong, Zhaoqing; Zhang, Xueji; Wu, Song

doi:10.1021/acsabm.2c00565

Cited by 10 publications

(2 citation statements)

References 45 publications

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“…Although micro/nanorobots have been explored to treat diabetes, [187] cardiovascular diseases, [188][189][190] and infected diseases in various parts of the body (e.g., respiratory system, gastrointestinal tract); [30,33,191] assist in reproduction [50] and brain vasculature; [192] and even kill tumors, [193] the development of micro/nanorobots, including microgrippers, is still in its infancy, and there is a long way to go before clinical application. Current research on microgrippers is still in the proof-of-concept stage.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Untethered Microgrippers for Precision Medicine

Zhou,

Zhang,

Liu

et al. 2023

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Microgrippers, a branch of micro/nanorobots, refer to motile miniaturized machines that are of a size in the range of several to hundreds of micrometers. Compared with tethered grippers or other microscopic diagnostic and surgical equipment, untethered microgrippers play an indispensable role in biomedical applications because of their characteristics such as miniaturized size, dexterous shape tranformation, and controllable motion, which enables the microgrippers to enter hard‐to‐reach regions to execute specific medical tasks for disease diagnosis and treatment. To date, numerous medical microgrippers are developed, and their potential in cell manipulation, targeted drug delivery, biopsy, and minimally invasive surgery are explored. To achieve controlled locomotion and efficient target‐oriented actions, the materials, size, microarchitecture, and morphology of microgrippers shall be deliberately designed. In this review, the authors summarizes the latest progress in untethered micrometer‐scale grippers. The working mechanisms of shape‐morphing and actuation methods for effective movement are first introduced. Then, the design principle and state‐of‐the‐art fabrication techniques of microgrippers are discussed. Finally, their applications in the precise medicine are highlighted, followed by offering future perspectives for the development of untethered medical microgrippers.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Untethered Microgrippers for Precision Medicine

Zhou,

Zhang,

Liu

et al. 2023

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“…CTP, as a representative of carbonized CHMs, is obtained by stir‐frying (Gao, Lan et al, 2021). CTP possesses a significant hemostatic effect and is therefore clinically applied as a remedy for hemorrhage syndromes, including hematemesis, epistaxis, hemoptysis, hematochezia, and uterine bleeding (Ohkura et al, 2011; Yang, Tang, et al, 2022). CTP is listed in the Chinese Pharmacopoeia (2020), edition, as well as in the Standards of Chinese Herbal Medicines published by various provinces of China.…”

Section: Introductionmentioning

confidence: 99%

A novel strategy for the quality control of carbonized Typhae pollen using colorimeter, liquid chromatography–mass spectrometry, and efficacy evaluation coupled with multivariate statistical analysis

Jiaqi,

Min,

Yongqi

et al. 2024

Biomedical Chromatography

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In this study, a novel quality control strategy was proposed, aiming to establish a multivariate specification for the processing step by exploring the correlation between colors, chemical components, and hemostatic effects of the carbonized Typhae pollen (CTP) using multivariate statistical analysis. The CTP samples were stir‐fried at different durations. Afterward, the colorimeter and LC–MS techniques were applied to characterize the CTP samples, followed by the determination of bleeding time and clotting time using mice to evaluate their hemostatic effect. Then, principal component analysis, hierarchical cluster analysis, and multi‐block partial least squares were used for data analysis on colors, chemical components, and their correlation with the hemostatic effect. Consequently, 13 critical quality attributes (CQAs) of CTP were identified via multivariate statistical analysis—L*, a*, b*, 3,4‐dihydroxybenzoic acid, 4‐hydroxybenzoic acid, 3‐hydroxybenzoic acid, quercetin‐3‐O‐glucoside, azelaic acid, kaempferol‐3‐O‐glucoside, quercetin, naringenin, kaempferol, and isorhamnetin. The multivariate specification method involving the 13 CQAs was developed and visualized in the latent variable space of the partial least squares model, indicating that the proposed method was successfully applied to assess the quality of CTP and the degree of carbonization. Most importantly, this study offers a novel insight into the control of processing for carbonized Chinese herbal medicines.

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Magnetically Powered Immunogenic Macrophage Microrobots for Targeted Multimodal Cancer Therapy

Cong

Xie

et al. 2023

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Motile microrobots open a new realm for disease treatment. However, the concerns of possible immune elimination, targeted capability and limited therapeutic avenue of microrobots constrain its practical biomedical applications. Herein, a biogenic macrophage‐based microrobot loaded with magnetic nanoparticles and bioengineered bacterial outer membrane vesicles (OMVs), capable of magnetic propulsion, tumor targeting, and multimodal cancer therapy is reported. Such cell robots preserve intrinsic properties of macrophages for tumor suppression and targeting, and bioengineered OMVs for antitumor immune regulation and fused anticancer peptides. Cell robots display efficient magnetic propulsion and directional migration in the confined space. In vivo tests show that cell robots can accumulate at the tumor site upon magnetic manipulation, coupling with tumor tropism of macrophages to greatly improve the efficacy of its multimodal therapy, including tumor inhibition of macrophages, immune stimulation, and antitumor peptides of OMVs. This technology offers an attractive avenue to design intelligent medical microrobots with remote manipulation and multifunctional therapy capabilities for practical precision treatment.

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Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment

Cited by 10 publications

References 45 publications

Untethered Microgrippers for Precision Medicine

Untethered Microgrippers for Precision Medicine

A novel strategy for the quality control of carbonized Typhae pollen using colorimeter, liquid chromatography–mass spectrometry, and efficacy evaluation coupled with multivariate statistical analysis

Magnetically Powered Immunogenic Macrophage Microrobots for Targeted Multimodal Cancer Therapy

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