Many chemicals are applied for disinfecting purposes. Although chlorination is the most common procedure, it has many drawbacks. So there becomes an urgent need for new chemicals which are both effective and less harmful to other water fauna. The present work aims at investigating the comparative effects of chlorine and Huwa-san as a new disinfectant on Biomphalaria alexandrina snails which act as bioindicators of toxicity, besides evaluating their miracicidal and cercaricidal activities. The results showed that Huwa-san was more toxic on tested snails than chlorine, where the LC values were 21 and 1368.9 ppm, respectively after 24 h. Also, it was found that the activities of catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), and glutathione peroxidase (GPX) in snails' tissues were either induced or inhibited according to the tested disinfectant. Regarding reduced glutathione (GSH) content, it was increased as chlorine concentrations increased, while it reached its minimum content at the highest Huwa-san concentration. Such fluctuations were supported by histopathological examination of digestive and hermaphrodite glands, as prolonged exposure to chlorine led to more detrimental effects than Huwa-san concentrations. Moreover, Huwa-san was more effective on Schistosoma mansoni miracidia than on its cercariae, while the reverse was observed with chlorine. In conclusion, Huwa-san as a newly applied disinfectant can also be used as miracicidal and cercaricidal agent at small concentrations. Despite being more toxic to B. alexandrina snails, the chronic effect of its sublethal concentrations is less harmful than chlorine.