This study focuses on the assessment of forest cover and disturbance changes in the heavily polluted Ore Mountains (Czechia, Central Europe) during the second half of the 20th century and onward. It analyzes the driving forces of forest changes with reference to environmental, societal and political development in the region. Anthropogenic air pollution, prevalently SO 2 from adjacent coal-burning industry, caused extensive forest decline, especially between the 1970s and 1980s. The most affected tree species was the main economical timber species, Norway spruce, which proved to be remarkably pollution-sensitive. We used Landsat time series, and a combination of an integrated forest Z-score and Disturbance Index (DI), to analyze the forest cover change and disturbance development during 1985-2016. In 1994, the forest cover reached its minimum there. The breakdown of communism in the 1990s implied fulfilling EU pollution standards via air protection regulations, investment in power plant desulphurization, and forest management measures, which were the main drivers of the forest recovery. The forest recovery continued till about 2005; however, fluctuations in forest cover and DI have continued during the last decade. Apparently, forests weakened by old loads are prone to new stress factors. Landsat time series represent a powerful data source to monitor the impact of these drivers on forests on a regional scale. Originally, the severely damaged eastern part with heavier acidic load and large forest decline recovered faster after remarkable lowering of air pollution loads compared to the western part, with lower loads and less damaged forests. However, the interactions of persisting driving forces (soil acidification, adverse meteorological events, climate change factors, air pollution, tree species composition and physiological state, pest outbreaks) still threaten the forests there, which remain moderately damaged in both parts of the Ore Mountains. This may lead to unpredictable forest development independently of societal and political driving forces.