Pollution free UV-C radiation to mitigate COVID-19 transmission

Kumar, Ashok; Raj, Abhishek; Gupta, Ankit; Gautam, Sneha; Kumar, Manish; Bherwani, Hemant; Anshul, Avneesh

doi:10.1016/j.gr.2022.07.010

Cited by 12 publications

(3 citation statements)

References 104 publications

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“…Ultraviolet radiation (UV-A, UV-B, UV-C) can cause double-stranded DNA breaks (DSBs) [88,89], which results in cell cycle arrest through the recruitment of ATM (ataxiatelangiectasia mutated) protein kinase that mobilizes one of the most extensive signaling networks as an attempt to repair them, and when it is not possible, the apoptosis pathway is triggered by P53 protein [90,91]. Although studies are still very limited, there is already evidence that cellular exposure to this type of radiation can influence the transcription of satDNA sequences.…”

Section: The Pathways Of Dna Damage Response (Ddr) Encompass Satellit...mentioning

confidence: 99%

Answering the Cell Stress Call: Satellite Non-Coding Transcription as a Response Mechanism

Fonseca-Carvalho,

Veríssimo,

Lopes

et al. 2024

Biomolecules

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Organisms are often subjected to conditions that promote cellular stress. Cell responses to stress include the activation of pathways to defend against and recover from the stress, or the initiation of programmed cell death to eliminate the damaged cells. One of the processes that can be triggered under stress is the transcription and variation in the number of copies of satellite DNA sequences (satDNA), which are involved in response mechanisms. Satellite DNAs are highly repetitive tandem sequences, mainly located in the centromeric and pericentromeric regions of eukaryotic chromosomes, where they form the constitutive heterochromatin. Satellite non-coding RNAs (satncRNAs) are important regulators of cell processes, and their deregulation has been associated with disease. Also, these transcripts have been associated with stress-response mechanisms in varied eukaryotic species. This review intends to explore the role of satncRNAs when cells are subjected to adverse conditions. Studying satDNA transcription under various stress conditions and deepening our understanding of where and how these sequences are involved could be a key factor in uncovering important facts about the functions of these sequences.

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Section: The Pathways Of Dna Damage Response (Ddr) Encompass Satellit...mentioning

confidence: 99%

Answering the Cell Stress Call: Satellite Non-Coding Transcription as a Response Mechanism

Fonseca-Carvalho,

Veríssimo,

Lopes

et al. 2024

Biomolecules

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“…Within this context, a number of studies have highlighted the potential for UV-C light as a means of mitigating the transmission of SARS-CoV-2 in indoor settings. UV-C can be used for sanitization of surfaces and sterilization of aerosols and offers a safer alternative to chemical-based treatments like hydrogen peroxide vaporization [ 16 ]. Noteworthy is the finding that UV-C light doses of 34.9–52.5 mJ/cm 2 can inactivate SARS-CoV-2 on surfaces [ 17 , 18 , 19 ], while 21.4 mJ/cm 2 dosing can inactivate SARS-CoV-2 in the air [ 20 ] over brief exposure durations.…”

Section: Introductionmentioning

confidence: 99%

UV-C Light Intervention as a Barrier against Airborne Transmission of SARS-CoV-2

Ragan,

Perez,

Davenport

et al. 2024

Viruses

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Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode of transmission. In addition to tools like vaccination and testing, countermeasures that reduce viral spread in indoor settings are critical. This study aims to assess the efficacy of UV-C light, utilizing the Violett sterilization device, as a countermeasure against airborne transmission of SARS-CoV-2 in the highly susceptible Golden Syrian hamster model. Methods: Two cohorts of naïve hamsters were subjected to airborne transmission from experimentally infected hamsters; one cohort was exposed to air treated with UV-C sterilization, while the other cohort was exposed to untreated air. Results: Treatment of air with UV-C light prevented the airborne transmission of SARS-CoV-2 from the experimentally exposed hamster to naïve hamsters. Notably, this protection was sustained over a multi-day exposure period during peak viral shedding by hamsters. Conclusions: These findings demonstrate the efficacy of the UV-C light to mitigate against airborne SARS-CoV-2 transmission. As variants continue to emerge, UV-C light holds promise as a tool for reducing infections in diverse indoor settings, ranging from healthcare facilities to households. This study reinforces the urgency of implementing innovative methods to reduce airborne disease transmission and safeguard public health against emerging biological threats.

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“… Kumar et al (2023) reported a review article on Pollution free UV-C radiation to mitigate COVID-19 transmission. The high rate of transmission of the COVID-19 virus has brought various types of disinfection techniques, for instance, hydrogen peroxide vaporization, microwave-generating steam, UV radiation, dry heating, etc.…”

Section: Introductionmentioning

confidence: 99%