Poloxamer-based nanogels as delivery systems: how structural requirements can drive their biological performance?

Shriky, Bana; Vigato, Aryane Alves; Sepulveda, Anderson Ferreira; Machado, Isabel Daufenback; Araújo, Daniele Ribeiro de

doi:10.1007/s12551-023-01093-2

Cited by 6 publications

(1 citation statement)

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“…In this context, many efforts have been carried out to improve the gel performances, stability over time, viscoelastic and biological properties of PL gels [ 6 , 12 , 13 , 14 , 15 , 16 ]. Polysaccharide addition appears to be a convenient way to ensure the shape stability, gel stabilization against dissolution [ 12 , 17 ] and biocompatibility [ 18 ] of PL-based systems. The gels are stabilized by the interactions of long polysaccharide chains with PEO blocks, which can be combined with the hydrophobic interactions of hydrocarbon chains (>C16) with the core of the Pluronic micelles [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides

Lupu,

Gradinaru,

Rusu

et al. 2023

Gels

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Thermoresponsive Pluronic® F127 (PL) gels in water were investigated through rheological tests in different shear conditions. The gel strength was tuned with the addition of 1% polysaccharide solution. In the presence of xanthan gum (XG), the viscoelastic behavior of PL-based hydrogels was improved in aqueous environment, but the rheological behavior was less changed with the addition of XG in PBS solutions, whereas in the presence of 0.1 M NaCl, the viscoelastic parameters decreased. PL micellar networks exhibited a self-healing ability, recovering their initial structure after applying cycles of high strain. The rheological characteristics of the PL hydrogel changed with the addition of 1% polysaccharides (xanthan gum, alginate, κ-carrageenan, gellan, or chitosan). PL/polysaccharide systems form temperature-responsive hydrogels with shear thinning behavior, yield stress, and self-healing ability, being considered a versatile platform for injectable biomaterials or bioinks. Thus, in the presence of xanthan gum in aqueous medium, the gel strength was improved after applying a high strain (the values of elastic modulus increased). The other investigated natural polymers induced specific self-healing behaviors. Good performances were observed with the addition of gellan gum, alginate, and κ-carrageenan, but for high values of strain, the ability to recover the initial structure decreased. A modest self-healing behavior was observed in the presence of chitosan and xanthan gum dissolved in NaCl solution.

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