Poly(2‐(dimethylamino) ethyl methacrylate)‐b‐poly(lauryl methacrylate)‐b‐poly(oligo ethylene glycol methacrylate) triblock terpolymer micelles as drug delivery carriers for curcumin

Abstract

This work aims to investigate the ability of poly[2‐(dimethylamino)ethyl methacrylate‐b‐lauryl methacrylate‐b‐(oligo ethylene glycol)methacrylate], PDMAEMA‐b‐PLMA‐b‐POEGMA amphiphilic triblock terpolymers, to encapsulate the model hydrophobic compound curcumin. The terpolymers were synthesized by RAFT polymerization methodologies at variable molecular weights and compositions and self‐assemble into spherical micelles with mixed PDMAEMA/POEGMA coronas and PLMA cores, when inserted in aqueous solutions. Fourier transform infrared and UV–Vis spectroscopy measurements were utilized in order to confirm and quantify the encapsulation of curcumin within the polymeric micelles respectively. Dynamic light scattering was used for the investigation of the size of the nanostructures formed and transmission electron microscopy proved that their morphology is spherical. Moreover, the colloidal stability of the systems in physiological conditions was assessed and two independent in vitro cytotoxicity assays revealed that curcumin‐loaded PDMAEMA‐b‐PLMA‐b‐POEGMA micelles were not cytotoxic.

Single Functional Group Platform for Multistimuli Responsivities: Tertiary Amine for CO2/pH/ROS-Triggered Cargo Release in Nanocarriers

“…It is interesting to note that Cur-TA-MP2 showed an overall higher DL % and EE % compared to Cur-MP1, which may suggest a stronger drug–polymer interaction due to additional hydrophobicity in the core environment of Cur-TA-MP2. Cur-TA-MP2 had EE % of >80%, which was significantly higher than the Cur-loaded micelles from a linear triblock copolymer, poly[2-(dimethylamino)ethyl methacrylate- b -lauryl methacrylate- b -(oligo ethylene glycol)methacrylate] of about 12% …”

Non‐Viral Nucleic Acid Delivery System for RNA Therapeutics

“…Poly (2‐(dimethylamino) ethyl methacrylate) (pDMAEMA) is a water‐soluble cationic polymer, which can electrostatically interact with DNA and form a stable polyelectrolyte complex. [ 145 ] The transfection efficiency of pDMAEMA was improved with the increase of polymer molecular weight. Since the average pKa of amino group is 7.5, the tertiary amino group of pDMAEMA has been partially protonated in physiological solution, so it can have certain proton buffering in the acid endosomal compartment.…”

Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage

“…The current study investigates the synthesis of a series of homopolymeric and copolymeric injectable hydrogels based on PEGMEM and DMAEM for their use in cartilage regeneration. Both monomers have been reported to be used for several biomedical applications [ 27 , 28 , 29 , 30 ]; however, the safety of polymers based on DMAEM is still controversial [ 31 , 32 , 33 ]. The previously described synthesis procedure [ 26 ] was modified to obtain more flowable hydrogel to fulfill the injectability requirement.…”