Poly(2-hydroxyethylmethacrylate-<i>co</i>-2-folate ethylmethacrylate) and Folic acid/Poly(2-hydroxyethylmethacrylate) Solid Solution: Preparation and Drug Release Investigation

Beagan, Abeer M.; Aouak, Taı̈eb; AlJuhaiman, Layla Abdulkarim; Alodainy, Abdelbasit Mohammed; Saeed, Waseem Sharaf; Smane, Mohamed Oulad

doi:10.1080/03602559.2017.1298799

Cited by 5 publications

(2 citation statements)

References 58 publications

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“…In X-ray diffractograms of the folate complexes, major patterns were scanned within the 4° to 80° 2 θ range. The XRD patterns of the folate complexes ( Figure 6 ) are completely different from those of folic acid [ 38 ] due to the formation of new coordination compounds. The X-ray diffractogram of the three synthesized metal-folate complexes is semicrystalline as well as amorphous in nature.…”

Section: Resultsmentioning

confidence: 99%

Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics

El-Habeeb

2020

Bioinorganic Chemistry and Applications

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In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses. The synthesized folate complexes were also subject to thermal analysis (TGA) to better examine their thermal degradation and kinetic properties. The folate complexes had high stability and were nonspontaneous. The Coats–Redfern and Horowitz–Metzger equations were used to determine thermodynamic parameters and describe the kinetic properties. These complexes were synthesized through the chemical interactions in neutralized media between the folic acid drug ligand (FAH2) with GaCl3, GeCl4, and HfCl4 metal salts at 1 : 2 (metal : ligand) molar ratio. The conductance measurements have low values due to their nonelectrolytic behavior. The X-ray powder diffraction solid powder pattern revealed a semicrystalline nature. In vitro, we screened the synthesized folate chelates for antibacterial and antifungal activities. The inhibition of four bacterial and two fungi pathogens (E. coli, B. subtilis, P. aeruginosa, S. aureus, A. flavus, and Candida albicans) was improved using a folic acid drug relative to the control drug.

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Section: Resultsmentioning

confidence: 99%

Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics

El-Habeeb

2020

Bioinorganic Chemistry and Applications

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“…CNC/APTES showed the same XRD pattern as neat CNC, indicating no influence of APTES on crystallinity. The XRD pattern of CNC/APTES/FA revealed a new peak at 27.3º which comes from FA crystals(Beagan et al, 2017), although this peak was not indexed. The XRD of CNC/APTES/FA/Cdots showed a similar pattern to that of CNC/APTES/FA although the peak at 27.3º was more intense.…”

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confidence: 98%

A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy

Anh

Grijalvo

Imae

et al. 2021

Carbohydrate Polymers

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Synthesis and characterization of mesoporous silica-g-poly(hydroxyethylmethacrylate) nanohybrid particles as a drug delivery system

García-Uriostegui

Meléndez‐Ortiz²,

Camacho-Villegas

et al. 2022

Materials Chemistry and Physics

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Poly(2-hydroxyethylmethacrylate-co-2-folate ethylmethacrylate) and Folic acid/Poly(2-hydroxyethylmethacrylate) Solid Solution: Preparation and Drug Release Investigation

Cited by 5 publications

References 58 publications

Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics

Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics

A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy

Synthesis and characterization of mesoporous silica-g-poly(hydroxyethylmethacrylate) nanohybrid particles as a drug delivery system

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