Poly(3,4‐ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces

Abstract

GAGs coatings are performed using SH-SY5Y and CCF-STTG1 cell lines and with ATP and Ca(2+) . Results show full biocompatibility and a pronounced anti-inflammatory effect. This last characteristic becomes crucial if implanted in the body. These materials can be used for in vivo applications, as transistor or electrode for electrical recording and for all the possible situations when there is contact between electronic circuits and living tissues.

Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4‐Ethylenedioxythiophene):P‐Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography

“…From this perspective, the field of neuroelectrode engineering has encouraged the use of alternative electroactive materials over conventional metallic strategies such as gold and platinum as an approach to provide an electrochemical platform for the immobilization of biological molecules, or in order to promote physicomechanical mimicry through soft or topographically rough interfaces . Specifically, semiconducting polymers, including polypyrrole and poly(3,4‐ethylenedioxythiophene) (PEDOT), and their hybrids have been employed widely in neural engineering because of their versatility as electrode coatings through electrodeposition processes, and have been employed to enhance the neuroelectrode electrochemical profile, and provide a platform for chemical and morphological functionalization to meet particular requirements …”

Flexible and Organic Neural Interfaces: A Review

“…Now, the most commonly used material is PEDOT that can be doped with PSS as well as glycosaminoglycan to enhance its conductivity and/or its biocompatibility [126]. In a OECT, the source-to-drain current is modulated by ions penetrating the polymer hence doping/de-doping the material and consequently modulating the concentration of carriers contributing to the current [127].…”

A PSS‐Free PEDOT Conductive Film Supported by a Hierarchical Nanoporous Layer Glass

“…Among the conductive polymers, a composite of polyethylene dioxythiophene and polyethylene sulfonic acid (PEDOT/PSS) is widely researched because of its high electrical conductivity and excellent chemical stability . PEDOT/PSS conductive film is obtained by coating its colloidal dispersion, then drying a substrate, where PSS wraps PEDOT particle to form a core–shell structure .…”

“…PEDOT/PSS conductive film is obtained by coating its colloidal dispersion, then drying a substrate, where PSS wraps PEDOT particle to form a core–shell structure . Such a system is promising from the viewpoint of flexibility and freedom from rare metals, that promotes various researches and developments like conductivity improvement, substitution of PSS with biocompatible polymers, and application to a variety of devices . There are various commercially available PEDOT/PSS dispersions which form a film typically with its conductivity of 10 −5 –10 2 S cm −1 .…”

“…Among the conductive polymers, a composite of polyethylene dioxythiophene and polyethylene sulfonic acid (PEDOT/PSS) is widely researched because of its high electrical conductivity and excellent chemical stability. [3][4][5][6][7][8][9][10][11] PEDOT/PSS conductive film is obtained by coating its colloidal dispersion, then drying a substrate, where PSS wraps PEDOT particle to form a core-shell structure. [4] Such a system is promising from the viewpoint of flexibility and freedom from rare metals, [5] that Conductivity was measured by the four-terminal method using a LCR meter (NF Corp., ZM2376) under a condition of an applied voltage of 5 V. The measurement frequency was DC and between 50 mHz and 1 kHz.…”