Poly(3-hydroxyalkanoate)s: Diversification and biomedical applications

Hazer, Derya Burcu; Kılıçay, Ebru; Hazer, Baki

doi:10.1016/j.msec.2012.01.021

Cited by 225 publications

(129 citation statements)

References 124 publications

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“…In particular, the possibility to adjust material properties by controlling the monomeric composition, and functionalize it via introduction of vinyl groups is of great interest 1 . Whereas short-chain-length PHAs (scl-PHA, C4-C5 monomers) are readily available on the market 2,3 , largescale commercialization of mcl-PHA is still to be established.…”

Section: Introductionmentioning

confidence: 99%

Pilot-scale Production of Functionalized mcl-PHA from Grape Pomace Supplemented with Fatty Acids

Follonier

Riesen²,

Zinn

2015

Chem.Biochem.Eng.Q.

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Section: Introductionmentioning

confidence: 99%

Pilot-scale Production of Functionalized mcl-PHA from Grape Pomace Supplemented with Fatty Acids

Follonier

Riesen²,

Zinn

2015

Chem.Biochem.Eng.Q.

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“…scaffolding for the regeneration of nerve axons and arteries. Amphiphilic PHA copolymers have significant applications in drug delivery, tissue engineering and cardiovascular area, e.g., artery augments, vascular grafts, cardiologic stents, heart valves, implants, pericardial patches, microparticulate carriers, and dressing tablets 62 . PHB can be degraded to HB identified in high concentration in human blood.…”

Section: Phb Propertiesmentioning

confidence: 99%

“…mcl-PHA with decreased T g is soft and elastic, making it suitable for biomedical applications 62 . The chemical structure and monomer composition are efficiently influence the material and physical characteristics of PHAs 29,87,88 .…”

Section: Copolymers Productionmentioning

confidence: 99%

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Application of Poly(hydroxyalkanoate) In Food Packaging: Improvements by Nanotechnology

Khosravi‐Darani¹

2015

Chem.Biochem.Eng.Q.

128

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The environmental impact of plastic usage is of critical concern and too great to repair. A shift toward biodegradable food packaging is one option. The aim of this review paper is the study of the potential of biodegradable materials for food packaging. The main characteristics in relation to food usage can be narrowed down to mass transfer (gas and water vapor), thermal and mechanical properties. Among several kinds of biodegradable polymers, poly(hydroxyalkanoate) is one of the favorable candidates for food packaging due to its physical and mechanical properties, biodegradability, with low permeability for O 2 , H 2 O and CO 2 without residues of catalysts and water solubility. The main focus of this article is to address poly(hydroxyalkanoate) as a potential candidate for food packaging. The need of applying biobased polymers in food packaging is presented in the introduction of this study. We also describe the most common biopolymers providing a brief overview of classification and application. This is followed by an outline of biopolymer production and a main section in which the properties of poly(hydroxybutyrate)-based nanocomposites of greatest relevance to food packaging are discussed. Furthermore, several approaches for improvement of poly(hydroxybutyrate) properties are described and the role of nanotechnology to improve its mechanical properties is presented. Finally, the article concludes with a summary as well as some possible future trends.

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“…Furthermore, polyester nanoparticulate DDSs can be formed from either naturally occurring polymers such as chitosan [41] or PHAs [42][43][44], or from synthetic macromolecules such as PLA, PEG, PCL or PHAs. Indeed, PHAs can be advantageously both naturally (microbial PHAs) or synthetically (chemically) produced [43,[45][46][47][48][49][50][51][52][53][54][55][56][57]. Among the numerous PHAs, the ubiquitous biocompatible and biodegradable poly(3-hydroxybutyrate) (PHB) can be obtained from bacteria as isotactic PHB, while ROP of substituted -lactones provides a valuable entry into PHBs featuring various tunable microstructures (atactic, syndiotactic, isotactic) [58][59][60].…”

Section: Introductionmentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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Poly(3-hydroxyalkanoate)s: Diversification and biomedical applications

Cited by 225 publications

References 124 publications

Pilot-scale Production of Functionalized mcl-PHA from Grape Pomace Supplemented with Fatty Acids

Pilot-scale Production of Functionalized mcl-PHA from Grape Pomace Supplemented with Fatty Acids

Application of Poly(hydroxyalkanoate) In Food Packaging: Improvements by Nanotechnology

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

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