Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-based scaffolds for tissue engineering

Abstract

Development and selection of an ideal scaffold is of importance for tissue engineering. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a biocompatible bioresorbable copolymer that belongs to the polyhydroxyalkanoate family. Because of its good biocompatibility, PHBHHx has been widely used as a cell scaffold for tissue engineering. This review focuses on the utilization of PHBHHx-based scaffolds in tissue engineering. Advances in the preparation, modification, and application of PHBHHx scaffolds are discussed.

Review on the current status of polymer degradation: a microbial approach

“…Co-polymer Methyl, with propyl 10%HH×120 Medical applications (Babul et al 2013;Averous and Pollet 2012;Chang et al 2014;Coen and Dehority 1970;Xie et al 2009) Poly (hydroxybutyrate-cohydroxyvalerate) (PHBV)…”

Differential osteogenic potential of human adipose‐derived stem cells co‐cultured with human osteoblasts on polymeric microfiber scaffolds

“…PHB–BHA fibers showed good uniformity as well as porosity and have a looped morphology. With a diameter range from 500 nm to 2.5 µm, the fibers display a histomorphological similarity to the extracellular matrix of natural tissue . FESEM analysis showed the attachment of cells to the scaffold [Fig.…”

“…In this study, we have employed the use of a hybrid composite of electrospun fibrous scaffold material consisting of polyhydroxybutyrate and bovine hydroxyapatite (PHB–BHA). This was employed to create a 3D microenvironment as an attachment site for both cells . PHB is a member of the polyhydroxyalkanoate (PHA) family, which has been recognized as a natural biological polyester and has the potential for bone repair .…”

“…Wang et al have demonstrated that electrospun PHB nanofibers aid differentiation, especially into osteogenic lineages . Although it is biocompatible and biodegradable, PHB has poor bioactivity and does not have a suitable compressive modulus . In order to improve its strength and osteoconductivity, a combination of PHB with bioactive ceramic consisting of calcium phosphates (CaP) such as hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , (HA) has been employed.…”

Nanomaterials, Scaffolds, and Skin Tissue Regeneration

“…A drawback they have is the lack of participation in intercellular communications. Some of these synthetic species used in tissue regeneration were: poly-ε-caprolactone [ 8 ], Star-PEG incorporating heparin [ 7 ], poly-β-hydroxybutyrate alone and copolymerized with poly-β-hexanoate [ 9 ], poly(D-lactide-co-ε-caprolactone) [ 10 ], poly(lactic-co-glycolic) acid [ 11 ], poly(glycerol-sebacate) and poly(D,L-lactideco-glycolide) [ 7 ]. These synthetic polymers and co-polymers were easily made into scaffolds which triggered negligible infl ammatory response.…”