Poly(-3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Current advances in synthesis methodologies, antitumor applications and biocompatibility

Tebaldi, Marli Luiza; Maia, Ana Luiza Chaves; Poletto, Fernanda; Andrade, Fabrício Vieira de; Soares, Daniel Crístian Ferreira

doi:10.1016/j.jddst.2019.02.007

Cited by 94 publications

(54 citation statements)

References 103 publications

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“…Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), one of the most used polyhydroxyalkanoates (PHAs), is a linear, hydrophobic thermoplastic, and a semicrystalline polyester and biodegradable polymer. Its physical and chemical properties make it very attractive for several applications, such as a substitute for non-biodegradable polymers in medical uses such as antitumor and vascular system materials, as well as in pharmaceutical applications such as biocompatible drug delivery systems [ 2 , 3 , 4 ]. Moreover, PVBV-based materials have been used more and more in high performance food packaging, single-use and disposable items, housewares, electrical and electronics devices, agriculture and soil stabilization, adhesives, paints and coatings, and automotive parts [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Accelerated Weathering Effects on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/TiO2 Nanocomposites

et al. 2020

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The effect of accelerated weathering on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV-based nanocomposites with rutile titanium (IV) dioxide (PHBV/TiO2) was investigated. The accelerated weathering test applied consecutive steps of UV irradiation (at 340 nm and 0.76 W m−2 irradiance) and moisture at 50 °C following the ASTM D4329 standard for up to 2000 h of exposure time. The morphology, chemical structure, crystallization, as well as the mechanical and thermal properties were studied. Samples were characterized after 500, 1000, and 2000 h of exposure time. Different degradation mechanisms were proposed to occur during the weathering exposure and were confirmed based on the experimental data. The PHBV surface revealed cracks and increasing roughness with the increasing exposure time, whereas the PHBV/TiO2 nanocomposites showed surface changes only after 2000 h of accelerated weathering. The degradation of neat PHBV under moisture and UV exposure occurred preferentially in the amorphous phase. In contrast, the presence of TiO2 in the nanocomposites retarded this process, but the degradation would occur simultaneously in both the amorphous and crystalline segments of the polymer after long exposure times. The thermal stability, as well as the temperature and rate of crystallization, decreased in the absence of TiO2. TiO2 not only provided UV protection, but also restricted the physical mobility of the polymer chains, acting as a nucleating agent during the crystallization process. It also slowed down the decrease in mechanical properties. The mechanical properties were shown to gradually decrease for the PHBV/TiO2 nanocomposites, whereas a sharp drop was observed for the neat PHBV after an accelerated weathering exposure. Atomic force microscopy (AFM), using the amplitude modulation–frequency modulation (AM–FM) tool, also confirmed the mechanical changes in the surface area of the PHBV and PHBV/TiO2 samples after accelerated weathering exposure. The changes in the physical and chemical properties of PHBV/TiO2 confirm the barrier activity of TiO2 for weathering attack and its retardation of the degradation process.

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Section: Introductionmentioning

confidence: 99%

Accelerated Weathering Effects on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/TiO2 Nanocomposites

et al. 2020

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“…PHBV is a biocompatible, biodegradable, highly absorbent, non-toxic thermoplastic. Together, all these properties make it a promising candidate material for biomedical applications, such as the fabrication of cardiac stents [30], wound dressing [31], drug release [32] and antitumor applications [33]. More specifically in tissue engineering, PHBV is usually employed for scaffolds in bone tissue regeneration [34,35], absorbable surgical sutures [36], among others.Additionally, owing to its piezoelectric properties (piezoelectric coefficient of 1.3 pC/N, similar to human bone [12,37]), this polymer can provide electrical stimulation through mechanical solicitation and with a suitable degradation rate for a variety of tissue engineering applications [38,39].In addition to tissue engineering applications, PHBV has a wide range of industrial applications such as food packaging [40], cosmetics, personal care products (towels and diapers), helmets and panels for several automotive materials [41][42][43].…”

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confidence: 99%

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confidence: 99%

Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

et al. 2020

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Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental program allowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. The morphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe 3 O 4 ).Polymers 2020, 12, 953 2 of 15In particular, smart polymers are gaining increasing attention as substrates and scaffolds for tissue engineering applications mainly as electroactive substrates-mostly piezoelectric ones-such as poly(l-lactic acid) (PLLA) [5,6], poly(hydroxybutyrate) (PHB) [7], poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) [8,9] and poly(vinylidene fluoride) (PVDF) [10,11], among others. The ability of those materials to actively enhance and stimulate cellular differentiation processes has been already proven [12,13], based on their mechano-transduction characteristics, generating voltage upon mechanical stimulation and vice-versa [14]. Piezoelectricity is a property that appears in a diversity of human tissues, including DNA, bones or tendons, emphasizing the relevance of electrical and mechano-electrical stimulation in physiological processes [15,16]. In a different approach to apply mechanical and/or mechano-electrical signals, magnetoelectric materials have also proven their aptness for tissue engineering applications, with the particularity of allowing electrical stimulation of the materials and, therefore, on the cells cultured on them, through magnetic solicitation [17,18]. These materials can generate voltage upon magnetic stimulation through the coupling of the magnetostrictive effect (magnetic to mechanical) and piezoelectric effect (mechanical to electric) [19,20]. Magnetoelectric composites are thus achieved combining a piezoelectric polymer with magnetostrictive particles [21][22][23], and their potential for tissue engineering and enhancement of cellular di...

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“…The biocompatibility of these polymers was largely assessed, as reported in former scientific studies . For instance, PLA and PLGA biocompatibility was demonstrated in vivo through histological and immunologic tests after implantation of microspheres in rats; PCL biocompatibility was assessed through evaluation of the viability of L929 mouse fibroblasts cultured on films of the polymer; biocompatibility of POC was assessed by monitoring form and phenotype of porcine chondrocytes cultured on POC scaffolds; PGS biocompatibility was demonstrated using human cardiac mesenchymal stem cells and rat cardiac progenitor cells cultured on PGS membrane through evaluation of viability after staining with DAPI; biocompatibility of PHB was assessed by subcutaneous implantation in rats and evaluation of the inflammatory response on tissue after 4 and 12 weeks; silk biocompatibility was widely demonstrated both in vitro and in vivo for applications in wound healing and in tissue engineering of bone, cartilage, tendon, and ligament tissues …”

Section: Bioresorbable Materials and Dissolution Chemistrymentioning

confidence: 99%

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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Poly(-3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Current advances in synthesis methodologies, antitumor applications and biocompatibility

Cited by 94 publications

References 103 publications

Accelerated Weathering Effects on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/TiO2 Nanocomposites

Accelerated Weathering Effects on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/TiO2 Nanocomposites

Morphology Dependence Degradation of Electro- and Magnetoactive Poly(3-hydroxybutyrate-co-hydroxyvalerate) for Tissue Engineering Applications

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

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