Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

“…These scaffolds may constitute the "scaffolds of choice" in future developments and their combination with stem cells is of high interest [62,[224][225][226]. The use of bioactive glass and glass ceramic nanoparticles [10,44] and carbon nanotubes (CNTs) [89,227,228] as well as their combination with bioresorbable polymers [46][47][48]89,170,229] may also improve the environment to enhance cell attachment, proliferation, angiogenic and osteogenic properties as well as adding extra functionalities to the base scaffold. However, possible toxicity issues associated with nanoparticles and CNTs will have to be comprehensively investigated [89].…”

“…Bone tissue engineering is one of the most exciting future clinical applications of bioactive glasses. Both micron-sized and recently nanoscale particles [23,44,45] are considered in this application field, which includes also the fabrication of composite materials, e.g., combination of biodegradable polymers and bioactive glass [38,[46][47][48][49][50], as discussed in detail in §3.2. Bioactive silicate glasses exhibit several advantages in comparison to other bioactive ceramics, e.g., sintered hydroxyapatite, in tissue engineering applications.…”

“…In 2003, Boccaccini and Maquet [42] reported for the first time on the successful fabrication of porous foam-like bioactive glass containing poly(lactide-co-glycolide) (PLGA) composites, which exhibited well-defined, oriented and interconnected porosity. Since then, many studies have been carried out to optimize and investigate bone TE composite scaffolds concerning material combinations, bioactive properties, degradation characteristics [161,164,165,168], in vitro [47,[161][162][163]169] and in vivo behavior [47,164], as well as mechanical properties [50,81,160].…”

“…Extensive work has been also carried out to investigate the cellular response to bioactive glass containing composites concerning composition, particle concentration and particle size effect in vitro and in vivo [46][47][48][161][162][163][164]166,[169][170][171]174]. For example, Lu et al [179] showed that for PLGA/bioactive glass films (0, 10, 25, 50 wt %), the growth, mineralization and differentiation of human osteoblast-like SaOS-2 cells (Figure 15), as well as the kinetics of Ca-P layer formation and the resulting Ca-P chemistry were dependent on BG content.…”

Fabrication and Characterization of Electrospun PHA/Graphene Silver Nano-Composite Scaffold for Antibacterial Application

“…The degradation product of poly 3-hydroxybutrate (P3HB) is a common metabolite in all higher living beings which is an important aspect of PHA [11]. In recent years, poly 4-hydroxybutyrate (P4HB), poly 3-hydroxybutrate and copolymer poly 3-hydroxybutyrate-co-3-hydroxyhexanoate (PHBHHx) [12,13] has been widely used in the field of medicine to develop the biologically significant devices including sutures, cardiovascular scaffolds, orthopedic scaffolds, adhesion barriers, guided tissue repair, nerve guides, tendon repair and wound dressings [14][15][16][17][18][19]. The versatile structure of PHA could simply be modified through physical blending and chemical alteration to improve its efficacy for medicinal use.…”