Poly(ADP-ribose) Polymerase 1 (PARP-1) Binds to 8-Oxoguanine-DNA Glycosylase (OGG1)

Hooten, Nicole Noren; Kompaniez, Kari; Barnes, Janice; Lohani, Althaf; Evans, Michele K.

doi:10.1074/jbc.m111.255869

Cited by 106 publications

(106 citation statements)

References 56 publications

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“…Additionally, OGG1 activity in other sequence contexts was not altered significantly. It is noteworthy that several other proteins including APE1, x-ray repair cross-complementing protein 1, and poly(ADP-ribose) polymerase 1 influence the removal of 8-oxoG by OGG1 (63)(64)(65). Further studies that examine the influence of other BER proteins/co-factors on the coding potential (polymerase-dependent) and repair of 8-oxoG will provide insights into cooperative protein interactions that modulate the mutagenic potential of an important oxidative DNA lesion in a biologically important sequence context.…”

Section: Discussionmentioning

confidence: 99%

DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

Sassa

Beard

Prasad

et al. 2012

Journal of Biological Chemistry

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Background: Human 8-oxoguanine DNA glycosylase (OGG1) removes the mutagenic DNA lesion 7,8-dihydro-8-oxoguanine. Results: OGG1 activity is significantly decreased by an adjacent DNA mismatch. Conclusion: Tandem lesions can dramatically diminish base excision repair. Significance: Deamination of 5Ј-methylcytosine in CpG-rich DNA sequences prone to oxidative DNA damage could be a significant factor in the generation of G to T transversions hot spots.

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Section: Discussionmentioning

confidence: 99%

DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

Sassa

Beard

Prasad

et al. 2012

Journal of Biological Chemistry

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“…Histidinetagged homeodomain protein B3 (HOXB3) was obtained from Addgene (72), and GST-tagged OGG1 was a generous gift from Drs. Nicole Noren Hooten and Michele Evans (35). All proteins were expressed in the BL21 strain of E. coli and were induced with isopropyl ␤-D-thiogalactopyranoside.…”

Section: Methodsmentioning

confidence: 99%

“…Both OGG1 and NEIL1 were shown to bind to PARP-1 and stimulate its poly-(ADP-ribosyl)ation activity, thereby promoting the recruitment of downstream BER effectors such as XRCC1. In turn, PARP-1 inhibits the enzymatic activity of these DNA glycosylases (34,35). Globally, the above cited studies indicate that several proteins can participate in BER complex formation and modulate the enzymatic activities of distinct BER enzymes.…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

CUX2 Protein Functions as an Accessory Factor in the Repair of Oxidative DNA Damage

Pal

Ramdzan

Kaur

et al. 2015

Journal of Biological Chemistry

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Background: CUX2 contains three Cut repeat domains and is expressed in postmitotic neurons. Results: Cut repeats stimulate the OGG1 DNA glycosylase, and lower or higher CUX2 expression, respectively, delays or accelerates repair of oxidative DNA damage. Conclusion: CUX2 functions as an accessory factor in base excision repair. Significance: CUX2 contributes to the maintenance of genome integrity in long lived neurons.

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“…PARP1 ac vity and PARP1 content generally declines with age, but it was reported to be higher in cells from centenarians than in controls [915]. More recently, it has been reported that OGG1 and NEIL1, two of the mammalian base excision repair glycosylases, bind to PARP1 and s mulate its ac vity [916,917]. PARP1 has been iden fied as a therapeu c target in cancer, with its inhibi on intended to decrease the capacity for DNA repair in cancer cells damaged by radio-and chemotherapy [reviewed in 918].…”

Section: Brca1 and Brca2mentioning

confidence: 99%

DNA repair systems

Chakarov¹,

Petkova²,

Russev³

2014

Biodiscovery

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This paper provides detailed insight into the mechanisms of repair of different types of DNA damage and the direct molecular players (enzymes repairing the damage or tagging the damaged site for further processing; damage sensor molecules; other signalling and effector molecules). The gene c bases of diseases and condi ons associated with defec ve DNA repair are comprehensively reviewed, from the 'classic' severe diseases such as xeroderma pigmentosum and Cockayne syndrome to the much more subtle UV sensi vity syndromes. The review analyses the basic molecular mechanisms underlying the rela vely rare monogenic diseases of DNA repair and management of genome integrity as well as the common mul factorial diseases and condi ons with late onset that are associated with increased levels of oxida ve stress (metabolic syndrome, diabetes type 2, cardiovascular disease) and with accumula on of 'errors' in DNA (normal and pathological ageing phenotypes, various cancers). The role of cell cycle checkpoints in dividing cells and the mechanisms of decision-making for the fate of a damaged cell are discussed with regards to the cell homeostasis in normal and cancerous ssues. The role of major DNA damageassociated signalling and effector molecules (p53, ATM, poly-(ADP-ribose)-polymerase, DNA-dependent protein kinase, BRCA proteins, re noblastoma protein, and others) is discussed and illustrated with examples in the context of health and disease. DNA repair and programmed cell death are viewed together as a unified mechanism for limi ng the presence of damaged cells and cells with poten ally oncogenic transforma on in mul cellular organisms. Special a en on is paid to ageing as a natural phenomenon and an adap ve evolu onary mechanism, with a brief outline of 'successful ageing'. The differen al rates of repair of DNA in transcribed and nontranscribed regions of the genome and the specifici es of DNA repair profile in some types of cells (terminally differen ated cells, pluripotent stem cells, etc.) and in certain taxonomic groups (e.g. 'the rodent repairadox') are discussed with regards to replica ve ageing and the evolu onary processes on microand macroscale. The role of mutagenesis as a 'hit and miss' mechanism and the 'leakiness' of DNA repair for increasing gene c diversity in the course of individual life and on evolu onary scale and the phenomenology of ongoing molecular evolu on are extensively reviewed. Conflict of Interests:No poten al conflict of interest was disclosed by any of the authors. Types of DNA repair systemsIf you wish for peace, prepare for war.Publius Flavius Vege us Renatus, De Re Militari (circa 380 AD).DNA damage is a very broad term, encompassing many different types of lesions in DNA.Accordingly, DNA repair comprises many different types of pathways and mechanisms covering virtually every possible type of injury to the sequence or the structure of DNA.Accep ng Lewin's defini on of DNA damage "... any change that introduces a devia on from the usual double-helical structure" [1] , we may pre...

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Poly(ADP-ribose) Polymerase 1 (PARP-1) Binds to 8-Oxoguanine-DNA Glycosylase (OGG1)

Cited by 106 publications

References 56 publications

DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

CUX2 Protein Functions as an Accessory Factor in the Repair of Oxidative DNA Damage

DNA repair systems

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