Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers

Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs

“…More recently, a new class of air-stable cationic zero generation ruthenium-based metallodendrimers prepared using nitrile-functionalized poly(alkylidenamine) has been synthesized under the basis of the recognized activity of ruthenium compounds as anticancer drugs and the known stability of these dendrimers at physiological temperature [23]. Metallodendrimers 13-16 (Scheme 2) were synthesized by peripherally functionalization of the corresponding dendrimers with the ruthenium moieties, [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 ] + or [RuCl(dppe) 2 ] + [23]. For the synthesis of 13 and 15, solutions of the corresponding core with [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 Cl] (4.5 molar ratio) and TlPF 6 (4.5 molar ratio) in methanol were stirred at room temperature for approximately one day [23].…”

“…Metallodendrimers 13-16 (Scheme 2) were synthesized by peripherally functionalization of the corresponding dendrimers with the ruthenium moieties, [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 ] + or [RuCl(dppe) 2 ] + [23]. For the synthesis of 13 and 15, solutions of the corresponding core with [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 Cl] (4.5 molar ratio) and TlPF 6 (4.5 molar ratio) in methanol were stirred at room temperature for approximately one day [23]. The resulting mixture was filtered, the precipitate rapidly extracted with CH 2 Cl 2 and the solvent evaporated, affording the tetrakis-ruthenium dendrimers, 13 or 15, in the form of yellow products [23].…”

“…For the synthesis of 13 and 15, solutions of the corresponding core with [Ru(η 5 -C 5 H 5 )(PPh 3 ) 2 Cl] (4.5 molar ratio) and TlPF 6 (4.5 molar ratio) in methanol were stirred at room temperature for approximately one day [23]. The resulting mixture was filtered, the precipitate rapidly extracted with CH 2 Cl 2 and the solvent evaporated, affording the tetrakis-ruthenium dendrimers, 13 or 15, in the form of yellow products [23]. In the synthesis of 14 and 16, the five coordinate cis-[RuCl(dppe) 2 ][PF 6 ] complex (4.5 molar ratio) was stirred in 1,2-dichloroethane at 90 °C, for about two days [23].…”

“…The resulting mixture was filtered, the precipitate rapidly extracted with CH 2 Cl 2 and the solvent evaporated, affording the tetrakis-ruthenium dendrimers, 13 or 15, in the form of yellow products [23]. In the synthesis of 14 and 16, the five coordinate cis-[RuCl(dppe) 2 ][PF 6 ] complex (4.5 molar ratio) was stirred in 1,2-dichloroethane at 90 °C, for about two days [23]. After work-up, the compounds were dissolved in the minimum amount of CH 2 Cl 2 and purified by re-precipitation with Et 2 O, giving pure yellowish Complexes 14 or 16 [23].…”

“…In the synthesis of 14 and 16, the five coordinate cis-[RuCl(dppe) 2 ][PF 6 ] complex (4.5 molar ratio) was stirred in 1,2-dichloroethane at 90 °C, for about two days [23]. After work-up, the compounds were dissolved in the minimum amount of CH 2 Cl 2 and purified by re-precipitation with Et 2 O, giving pure yellowish Complexes 14 or 16 [23]. All the metallodendrimers were isolated in reasonably good yields (57%-74%).…”