Poly(butylene succinate)-based polyesters for biomedical applications: A review

Gigli, Matteo; Fabbri, Massimo; Lotti, Nadia; Gamberini, Rita; Rimini, Bianca; Munari, Andrea

doi:10.1016/j.eurpolymj.2016.01.016

Cited by 304 publications

(222 citation statements)

References 120 publications

(425 reference statements)

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“…PLLA [23] or cellulose nanocomposites [24]. Several paper have been devoted to study of plasma exposure on polymer/meta nanocomposites [25] or copolymers [26]. Different type of polymer formations were proposed as ideal candidates for cytocompatible substrates, the significant increase of their biocompatibility were observed for e.g.…”

Section: Introductionmentioning

confidence: 99%

Plasma activated perfluoroethylenepropylene for cytocompatibility enhancement

Slepička

Peterková

Rimpelová

et al. 2016

Polymer Degradation and Stability

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Section: Introductionmentioning

confidence: 99%

Plasma activated perfluoroethylenepropylene for cytocompatibility enhancement

Slepička

Peterková

Rimpelová

et al. 2016

Polymer Degradation and Stability

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“…Poly(butylene succinate) (PBS) is another polymer that in recent years has come to be considered as a green polymer. It has been commercially available since 1993 and is obtained from the petrochemical industry . However, one of the necessary monomers for PBS synthesis, succinic acid (SA), is currently produced by fermentation process .…”

Section: Introductionmentioning

confidence: 99%

“…Traditional uses of PBS have been restricted to environmental purposes, such as mulching films, bags, nonwoven sheets and textiles, catering products, and foams . But recently extensive research has been conducted into potential further applications of PBS as a biomaterial.…”

Section: Introductionmentioning

confidence: 99%

“…But recently extensive research has been conducted into potential further applications of PBS as a biomaterial. It is mainly being used as a scaffold in tissue repair, although PBS, and especially some copolymers, have also been used as constituents of controlled drug delivery systems . However, in the field of drugs microencapsulation, this polymer and its derivatives are still poorly explored.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

Ramón

Sáez²,

Gomes³

et al. 2018

Macromolecular Symposia

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Researching for new biomaterials intended for drug delivery systems has considerably intensified in recent years. There is an increasing interest in PBS (poly[butylene succinate]) and its copolymers as biomaterials due to the possibility of synthesis of the PBS from a renewable source. Among these copolymers, PBS‐PEG (poly[butylene succinate‐co‐polyethylene glycol]) is studied for materials that have shape memory and are biodegradable. However, to date, no research into the use of PBS‐PEG to prepare microspheres for drugs release has been reported. Herein, PBS‐PEGs with three PEG with different chain′s length were synthesized by polycondensation reaction and characterized by means of SEC, FTIR, DSC, TGA, and DRX. Naproxen loaded microspheres were prepared by an oil‐in‐water (o/w) single emulsion technique. The drug release was followed by UV‐Vis. The presence of PEG had a marked effect on the in vitro release profiles. The mathematical models employed show that the fundamental mechanism of release is diffusion when PEG is present in the polymer matrix of the particle.

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“…Besides the fixation of the polymer chains in the crystalline domains, the flexibility of the chain itself also influences the degradation behaviour to some extent. Hydrolytic and enzymatic degradation of poly(butylene succinate) and its copolymers have recently been reviewed, emphasizing the great influence of the low flexibility of polymer chains on their relatively slow hydrolysis rate [31]. Therefore, copolyesters with long aliphatic dicarboxylic acids exhibit a somewhat higher degradation rate than those with shorter ones [10]; however, this effect usually is masked by the much higher influence of the melting point.…”

Section: Cell Adhesion and Proliferationmentioning

confidence: 99%

Effect of Hydroxyapatite Nanoparticles on the Degradability of Random Poly(butylene terephthalate-co-aliphatic dicarboxylate)s Having a High Content of Terephthalic Units

et al. 2016

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Copolyesters derived from 1,4-butanediol and constituted also of aliphatic and aromatic dicarboxylate units in a molar ratio of 3:7 were synthesized by a two-step polycondensation procedure. Succinic, adipic, and sebacic acids were specifically selected as the aliphatic component whereas terephthalic acid was chosen as the aromatic moiety. The second synthesis step was a thermal transesterification between the corresponding homopolymers, always attaining a random distribution as verified by NMR spectroscopy. Hybrid polymer composites containing 2.5 wt % of hydroxyapatite (HAp) were also prepared by in situ polymerization. Hydroxyl groups on the nanoparticle surface allowed the grafting of polymer chains in such a way that composites were mostly insoluble in the typical solvents of the parent copolyesters. HAp had some influence on crystallization from the melt, thermal stability, and mechanical properties. HAp also improved the biocompatibility of samples due to the presence of Ca 2+ cations and the damping effect of phosphate groups. Interestingly, HAp resulted in a significant increase in the hydrophilicity of samples, which considerably affected both enzymatic and hydrolytic degradability. Slight differences were also found in the function of the dicarboxylic component, as the lowest degradation rates was found for the sample constituted of the most hydrophobic sebacic acid units.

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Poly(butylene succinate)-based polyesters for biomedical applications: A review

Cited by 304 publications

References 120 publications

Plasma activated perfluoroethylenepropylene for cytocompatibility enhancement

Plasma activated perfluoroethylenepropylene for cytocompatibility enhancement

Synthesis and Characterization of PEG‐PBS Copolymers to Obtain Microspheres With Different Naproxen Release Profiles

Effect of Hydroxyapatite Nanoparticles on the Degradability of Random Poly(butylene terephthalate-co-aliphatic dicarboxylate)s Having a High Content of Terephthalic Units

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