Poly(caprolactone) based magnetic scaffolds for bone tissue engineering

Abstract

Synthetic scaffolds for tissue engineering coupled to stem cells represent a promising approach aiming to promote the regeneration of large defects of damaged tissues or organs. Magnetic nanocomposites formed by a biodegradable poly(caprolactone) (PCL) matrix and superparamagnetic iron doped hydroxyapatite (FeHA) nanoparticles at different PCL/FeHA compositions have been successfully prototyped, layer on layer, through 3D bioplotting. Magnetic measurements, mechanical testing, and imaging were carried out to calibrate both model and technological processing in the magnetized scaffold prototyping. An amount of 10% w/w of magnetic FeHA nanoparticles represents a reinforcement for PCL matrix, however, a reduction of strain at failure is also observed. Energy loss (absorption) measurements under a radio-frequency applied magnetic field were performed in the resulting magnetic scaffolds and very promising heating properties were observed, making them very useful for potential biomedical applications.

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

“…The chemical formula of HA is Ca 10 (PO 4 ) 6 (OH) 2 and it is known as pentacalcium hydroxide tris (orthophosphate) [6][7][8]. In the last twenty years, enormous attention has been given to the HA-based filler reinforcement for polymer matrices for plausible biomedical applications such as tissue engineering [9]. Hence, there is increasing interest in the development of novel hybrids and nano-powders to be incorporated into suitable polymers to confer better mechanical properties [10][11][12].…”

Proliferation and differentiation of mesenchymal stem cells on scaffolds containing chitosan, calcium polyphosphate and pigeonite for bone tissue engineering

“…[11][12][13][14] Nanophase ceramics have gained increasing attention because of their superior bioactivity as well as structural and compositional similarity to bone extracellular matrix.…”

Design, construction and mechanical testing of digital 3D anatomical data-based PCL–HA bone tissue engineering scaffold

“…As for the ABTES that has larger area or complex shape, how to get the accurate 3d anatomical data for its construction is a much more difficult problem, especially in the customized ABTES study, how to get the individualized anatomical data, and to design based on the lesionindividualized data, thus getting the proper 3D morphology of scaffold that could repair and reconstruct, is one of the difficulties in ABTES construction [12,[17][18][19][20][21]25]. In 1988, Geol took advantage of CT geometrical scanning to reconstruct the human digital model, but the meshing accuracy of CT-based digitized human anatomical model was very low, it was difficult to ensure the accuracy of model solution results [26].…”

“…The BTE scaffold materials vary widely, and many have been tried towards the repairing of bone defects, such as HA, PLA, polyamide, and chitosan. The current hot spot is to find and use the degradable materials, or the combination of degradable (MR Functional Nano-HA [18], superparamagnetic iron doped HA nanoparticles [19], nanocomposite magnetic scaffolds [20], RGD [12], and homogeneously plasma [21], etc.) and non-degradable materials, to construct the 3d tissue engineering scaffold, providing the cells a 3d growth space, at the same time, the scaffold itself has the biological activity, which could induce the cell differentiation and vascular ingrowth [22,23].…”