Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

Abstract

Food waste valorization practices have gained considerable attention focusing on the conversion of the waste into valuable products. In this context, the present study provides an insight into a new Eudragit RS100 based nanosystem as a carrier of date palm (Phoenix dactylifera L.) seeds oil known for its an antidiabetic activity. A priori systematic study was carried out in order to understand the individual impact of all contributing factors considered by the nanoprecipitation method. Then, date seeds oil nanoparticles were prepared, characterized and analyzed for their in vitro inhibition activity against: α-amylase and α-glucosidase. The results showed that the developed nanoparticles had an average diameter around 207 nm, a ζ-potential of +59 mV, and an encapsulation efficiency equal to 97 ± 1% with a loading capacity of 0.48 mg•mg −1 . The α-amylase and α-glucosidase IC 50 were found to be 87.6 and 155.3 μg•mL −1 , respectively. Therefore, this study may surely open new perspectives for the development of novel health-promoting plant oils loaded-nanocarriers for several purposes.

Nanocapsules containing Saussurea lappa essential oil: Formulation, characterization, antidiabetic, anti-cholinesterase and anti-inflammatory potentials

“…Higher ζpotential values were found for SL-EO loaded-NP as compared to free NP due to the interaction of the EO with PMMA polymer. This result was in accordance with our previous study when encapsulating Phoenix dactilyfera seeds oil (Lammari et al, 2020a).…”

“…According to Table 2, the average size (Z-average) of the PMMA-NP entrapped with SL-EO was significantly higher than that of blank NP (p < 0.05). Similar results were already reported in the literature (Lammari et al, 2020a;Rosset et al, 2012). The ζ-potential represents the overall surface charge that a particle acquires in a particular medium and it serves as a key indicator of the dispersion stability.…”

“…The expected benefits from the encapsulation of plant-based products included an enhanced aqueous solubility and bioavailability, a better protection from the environment (pH, temperature, humidity and oxygen) and a persistent delivery (Bilia et al, 2014). Several studies have been dedicated to the encapsulation of plant derived-metabolites such as essential oil (EO) (Chifiriuc et al, 2017;El-Asbahani et al, 2015;Froiio et al, 2019;Herculano et al, 2015;Jummes et al, 2020;Partheniadis et al, 2020;Pina-Barrera et al, 2019;Timbe et al, 2020), vegetable oils (Contri et al, 2013(Contri et al, , 2016Lammari et al, 2020a;Sousa et al, 2013), plants extracts (Azeez et al, 2020;Mughees et al, 2020;Servat-Medina et al, 2015), etc. However, to the best of our knowledge, neither the extract nor the EO of costus roots have been previously encapsulated in polymeric nanoparticles.…”

“…PMMA-NP were prepared by means of the nanoprecipitation technique (Fessi et al, 1989) using a protocol that was already described and studied systematically throughout the blank nanoparticles preparation (Lammari et al, 2020a) and according to which 220mg of PMMA was dissolved in 15mL of ethanol and then mixed with 120mg SL-EO. Consecutively the prepared organic phase was added carefully and very slowly to the aqueous phase consisting of 30 mL water at ambient temperature and under moderate magnetic stirring.…”

Pilot‐scale hydraulic‐pressure extraction of Sukari date honey (Phoenix dactylifera L.) to enhance resource efficiency: Effects of processing parameters on bioactive compounds and physicochemical quality

“…Date palm ( Phoenix dactylifera L.) plays a vital role in human life as it has been used for many needs, such as a rich source of energy, vitamins, and bioactive compounds (Lammari et al, 2020). It has also been used as an important material in nanotechnology (Ma'abreh, Abu‐Salah, Al‐Awaadh, & Mohamed, 2018).…”