Poly(ethylene glycol)‐Coated Magnetite Nanoparticles: Preparation and Characterization

Amici, Julia; Celasco, Edvige; Allia, Paolo; Tiberto, P.; Sangermano, Marco

doi:10.1002/macp.201000707

Cited by 11 publications

(8 citation statements)

References 25 publications

(42 reference statements)

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“…For the NP-DMSA sample, the spectrum was characterized by intense peaks assigned to Fe–O vibration in the region of 550–600 cm −1 [50] and a broad peak between 3000–3500 cm −1 corresponding to surface hydroxyl groups [51,52]. After PEG grafting, some bands appeared at 1354 and 1102 cm −1 , indicating asymmetric and symmetric stretching of C–O–C [53,54]. For nanoparticles conjugated to the bifunctional PEG derivative, an intense band appeared between 1000–1200 cm −1 after surface modification, indicating the presence of aliphatic polyether (C–O–C) and amide carbonyl vibration at 1640 and 1556 cm −1 [55,56].…”

Section: Resultsmentioning

confidence: 99%

Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles

et al. 2019

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Superparamagnetic iron oxide nanoparticles are one of the most prominent agents used in theranostic applications, with MRI imaging the main application assessed. The biomolecular interface formed on the surface of a nanoparticle in a biological medium determines its behaviour in vitro and in vivo. In this study, we have compared the formation of the protein corona on highly monodisperse iron oxide nanoparticles with two different coatings, dimercaptosuccinic acid (DMSA), and after conjugation, with a bifunctional polyethylene glycol (PEG)-derived molecule (2000 Da) in the presence of Wistar rat plasma. The protein fingerprints around the nanoparticles were analysed in an extensive proteomic study. The results presented in this work indicate that the composition of the protein corona is very difficult to predict. Proteins from different functional categories—cell components, lipoproteins, complement, coagulation, immunoglobulins, enzymes and transport proteins—were identified in all samples with very small variability. Although both types of nanoparticles have similar amounts of bonded proteins, very slight differences in the composition of the corona might explain the variation observed in the uptake and biotransformation of these nanoparticles in Caco-2 and RAW 264.7 cells. Cytotoxicity was also studied using a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Controlling nanoparticles’ reactivity to the biological environment by deciding on its surface functionalization may suggest new routes in the control of the biodistribution, biodegradation and clearance of multifunctional nanomedicines.

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Section: Resultsmentioning

confidence: 99%

Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles

et al. 2019

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“…The synthesis of hybrid nanoparticles consisting of MNPs and a polymer shell is not groundbreaking per se 35,36 ; however, the synthesis of such hybrid particles via thiol-ene polymerization of a vegetable oil-based monomer in miniemulsion has been scarcely reported in the literature. The studies mostly used thiol-ene as a tool for functionalization of hybrid nanoparticles (NPs) 37,38 or to prepare a preformed polymer and subsequently prepare the hybrid NPs thereof 39 rather than performing polymerization in situ. Since the first work on thiol-ene polymerization in miniemulsion in 2014, 22 a range of possibilities for new materials has been released and the in situ encapsulation of MNPs via thiol-ene polymerization has not been reported yet to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic biobased poly(thioether‐ester) via thiol‐ene polymerization in miniemulsion for hyperthermia

Santos

Machado

Santin

et al. 2020

J of Applied Polymer Sci

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Thiol-ene polymerization has been pointed out as a promising technique to produce biobased polymers for biomedical applications due to its advantages, including mild conditions and rapid reaction rates without the formation of byproducts. Therefore, in this study different concentrations of magnetic nanoparticles (MNPs) were incorporated in poly(thioether-ester) (PTEE) nanoparticles by thiol-ene miniemulsion polymerization of biobased monomers to form both linear and branched cross-linked polymers. Loading efficiencies up to approximately 95% (thermogravimetric analysis) of the MNPs within the polymer matrix were obtained. In addition, the substitution of the dithiol 1,4-butanedithiol (64.2%) for the tetrathiol PTEMP (95.8%), increased the encapsulation efficiency by about 30%. Hybrid nanoparticles presented average mean diameters between 95 and260 nm with polydispersity index between 0.13 and 0.42 by DLS, negative zeta potentials around −45 mV and superparamagnetic behavior. The hyperthermia assays performed on breast cells (MDA-MB 231) have shown that the cell death was dependent on the exposure time to the AC magnetic field and the reduction in cell viability was approximately 35%. These results demonstrated the production of superparamagnetic PTEE nanoparticles via thiol-ene polymerization and highlight the promising application of these biobased materials for cancer treatment by hyperthermia.

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“…This is particularly true if the polymerization reaction, as commonly happens, is thermally activated; in this case, the reaction can in fact last many hours. The reaction time is dramatically shorter (minutes vs. hours) if the emulsion polymerization is induced by UV irradiation, avoiding the problems related to instability of the emulsion that are typical of thermo‐induced polymerization . Overall emulsion polymerization can be used to produce both bulky and hollow (porous, core–shell) nanoparticles .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polymeric nanocapsules by radical UV-activated interface-emulsion polymerization

Bazzano

Pisano

Brelstaff

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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A new methodology is reported that allows a better control of the synthesis of polymeric core-shell nanocapsules. These nanocapsules were made of biocompatible polymers, obtained from poly(ethylene glycol)diacrylate and poly(ethylene glycol) methyl ether methacrylate, and were used as carrier for curcumin as therapeutic agent. The impact of manufacturing factors (time of sonication, time of UV irradiation, and type of monomer) was investigated in relation to the average size of nanocapsules, their distribution, shape, composition, stability, and their capability to deliver curcumin. We successfully synthesized core-shell nanocapsules in various sizes, ranging from 80 nm to 300 nm, by acting either on the process conditions or on the composition of the monomer mixture. This wide range of sizes makes the method here proposed very promising for the production of nanocarriers.

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Poly(ethylene glycol)‐Coated Magnetite Nanoparticles: Preparation and Characterization

Cited by 11 publications

References 25 publications

Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles

Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles

Superparamagnetic biobased poly(thioether‐ester) via thiol‐ene polymerization in miniemulsion for hyperthermia

Synthesis of polymeric nanocapsules by radical UV-activated interface-emulsion polymerization

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