Poly(ethylene glycol)-grafted poly(3-hydroxyundecenoate) networks for enhanced blood compatibility

Chung, Chung Wook; Kim, Hyung Woo; Kim, Young Baek; Rhee, Young Ha

doi:10.1016/s0141-8130(03)00020-5

Cited by 51 publications

(28 citation statements)

References 26 publications

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“…7 For example, PEG that contains acrylate groups were employed to prepare PHA-grafted copolymers by irradiation (Figure 3). 41 The presence of PEG chains in the polymer networks increased the hydrophilicity of the final product. The significant concentrations of water within the PHO-g-PEG polymers provided a low interfacial tension with blood and reduced the protein adsorption and platelet adhesion, which has been recognized as an essential requisite for materials that are employed in blood contacting devices.…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

“…The blood compatibility test confirmed the increasing trend due to an increased fraction of grafted PEG chains, which indicates the potential use of PHO-g-PEG polymer networks in blood-compatible biomedical applications. 41 In addition, the mechanical strength was optimized by the PEG concentration. In a typical example, the optimal tensile strength of the PHO-g-PEG (50/50, w/w) is 219 kPa, and the elongation at break is 379%, which indicated a significant improvement compared with the pure PHU polymers.…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

“…In a typical example, the optimal tensile strength of the PHO-g-PEG (50/50, w/w) is 219 kPa, and the elongation at break is 379%, which indicated a significant improvement compared with the pure PHU polymers. 41 Active radical sites along the polyhydroxyundecenoate (PHA) main chain can be created by abstracting the proton at the C-3 carbon in PHA to graft vinyl chains by monomer polymerization. 42 For example, when methyl mechacrylate (MMA) was polymerized in the presence of aqueous PHB suspension using benzoyl peroxide (BPO) as an Modified PHAs as engineering materials Z Li et al initiator, PMMA branches were able to graft on PHB by the covalent bonding between C-3 carbon of PHB and the vinyl CH of MMA repeating units (Figure 4).…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

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Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed.

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Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

See 1 more Smart Citation

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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“…19 After the platelets adhered on a surface, platelet aggregation and platelet spreading was observed, followed by thrombus formation, which potentially prevents the use of artificial materials in vivo. 53,54 Less adhesion, aggregation, and activation of platelets on a material surface, the better the blood compatibility of the material. 52,53 The degree of platelet activation could be judged to some extent by the degree of their pseudopod extension.…”

Section: Blood Compatibilitymentioning

confidence: 99%

Characterization, biodegradability and blood compatibility of poly[(R)‐3‐hydroxybutyrate] based poly(ester‐urethane)s

Liu

Cheng

Liu

et al. 2008

J Biomedical Materials Res

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Poly(ester-urethane)s (PUs) were synthesized using hexamethylene diisocyanate (HDI) or toluene diisocyanate (TDI) to join short chains (M(n) = 2000) of poly(R-3-hydroxybutyrate) (PHB) diols and poly(epsilon-caprolactone) (PCL) diols with different feed ratios under different reaction conditions. The multiblock copolymers were characterized by nuclear magnetic resonance spectrometer (NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), thermogravimetric analyses (TGA), X-ray diffraction (XRD), and scanning electron microscope (SEM). XRD spectra and second DSC heat thermograms of the multiblock copolymers revealed that the crystallization of both PHB and PCL segments was mutually restricted, and, especially, the PCL segment limited the cold crystallization of the PHB segment. The SEM of platelet adhesion experiments showed that the hemocompatibility was affected to some extent by the chain flexibility of the polymers. Hydrolysis studies demonstrated that the hydrolytic degradation of PUs was generated from the scission of their ester bonds or/and urethane bonds. Simultaneously, the rate of ester bond scission was determined to some extent by the crystallization degree, which was further affected by the configuration of polymer chains. These highly elastic multiblock copolymers combining hemocompatibility and biodegradability may be developed into blood contact implant materials for biomedical applications.

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“…Poly(hydroxyalkonate)s (PHA) are degradable, biocompatible and thermoplastic aliphatic polyesters produced by various microorganisms (Chung et al 2003). The most common type is the polyhydroxybutyrate (PHB) which is coming from the polymerization of 3-hydroxybutyrate monomer.…”

Section: Introductionmentioning

confidence: 99%