Poly(ethylene oxide) (PEO)-based ABC triblock terpolymers – synthetic complexity <i>vs.</i> application benefits

Barthel, Markus J.; Schacher, Felix H.; Schubert, Ulrich S.

doi:10.1039/c3py01666h

Cited by 52 publications

(43 citation statements)

References 150 publications

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“…By replacing PNIPAM with a statistic copolymer of poly(ethylene oxidestat‐butylene oxide), the micelle‐to‐vesicle transition was achieved within one week . Adopting a similar design method, reversible switch from micelle to high‐ordered structures was reported by other groups . However, most of the previous studies were focused on alteration in the packing parameter ( p ) of the responsive copolymers upon external stimuli.…”

Section: Introductionmentioning

confidence: 95%

“…So far, a number of groups addressed their attempts to reassemble ABC terpolymers in water, which usually contains three components, that is, hydrophilic, hydrophobic, and stimuli‐responsive segments. The hydrophilic unit aims to confer copolymer water solubility; the hydrophobic block contributes to the first level of self‐assembly; and the stimuli‐responsive segment provides the driving force of morphology transition.…”

Section: Introductionmentioning

confidence: 99%

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Morphology Transition of Dual‐Responsive ABC Terpolymer in Water: Effect of Hydrophobic Block

Luo

Wei

Luo

et al. 2018

Macro Chemistry & Physics

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To reveal the importance of hydrophobic block in morphology transition of responsive copolymers, four well‐defined ABC terpolymers with the same poly(dimethylamino ethyl methacrylate) (PDMAEMA) and PEG segments are synthesized by sequential RAFT polymerization. Poly (n‐hexyl methacrylate) (PnHMA), poly(n‐butyl methacrylate) (PnBMA), poly(ethyl methacrylate) (PEMA), and poly(methyl methacrylate) (PMMA), with glass transition temperatures of −5, 20, 65, and 100 °C, respectively, are selected as hydrophobic segments. The structures and compositions of four terpolymers, that is, mPEG45‐b‐PnHMA29‐b‐PDMAEMA28(EHD), mPEG45‐b‐PnBMA28‐b‐PDMAEMA32 (EBD), mPEG45‐b‐PEMA31‐b‐PDMAEMA30 (EED), and mPEG45‐b‐PMMA30‐b‐PDMAEMA29 (EMD), are confirmed by gel permeation chromatography and 1H NMR. Their morphology transitions in water are investigated via a combination of UV‐vis spectroscopy, light scattering, zeta potential measurements, and cryogenic transmission electron microscopy. All terpolymers can form spherical micelle by direct dissolution in acidic water. However, the spherical micelles of EBD and EHD progressively switch to cylinders and vesicles upon variations of external pH and temperature. In contrast, the spherical micelles of EMD and EED reversibly form larger aggregates when the temperature is above the cloud point of PDMAEMA in basic water. This study demonstrates the importance of hydrophobic block on the morphology transition of responsive copolymers.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Morphology Transition of Dual‐Responsive ABC Terpolymer in Water: Effect of Hydrophobic Block

Luo

Wei

Luo

et al. 2018

Macro Chemistry & Physics

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“…This will stabilize and prevent the metal nanoparticles from agglomerating. To date, ABC triblock copolymers have been used in conventional drug delivery systems [21][22][23][24] and also in the preparation of hollow inorganic nanoparticles [25][26][27][28][29]. However, to our knowledge, there are no reports on the employment of ABC triblock polymer as a stabilizer for the synthesis of stable and well-dispersed metal nanoparticles.…”

Section: Introductionmentioning

confidence: 95%

ABC triblock copolymer-stabilized gold nanoparticles for catalytic reduction of 4-nitrophenol

Dai

Wang

2015

Journal of Catalysis

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“…These nanostructured materials can be applied in several fields of interest such as nanotechnology, lithography and optolectronics. [2][3] Since physical properties and final performance are in direct relationship with the overall crystallinity and superstructural morphology of the constituent blocks, crystalline block copolymers have been extensively investigated and several reviews have been published in the past decade. 2,[4][5][6][7][8] In block copolymers with one or more crystallisable blocks, understanding of the final morphology upon crystallization is complicated since it is influenced by copolymer composition and segregation strength between the blocks.…”

Section: Introductionmentioning

confidence: 99%

Sequential crystallization and morphology of triple crystalline biodegradable PEO-b-PCL-b-PLLA triblock terpolymers

et al. 2016

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The sequential crystallization of poly(ethylene oxide)-b-poly(e-caprolactone)-b-poly(L-lactide) (PEO-b-PCL-b-PLLA) triblock terpolymers, in which the three blocks are able to crystallize separately and sequentially from the melt, is presented. Two terpolymers with identical PEO and PCL block lengths and two different PLLA block lengths were prepared, thus the effect of increasing PLLA content on the crystallization behavior and morphology was evaluated. Wide angle X-Ray scattering (WAXS) experiments performed on cooling from the melt confirmed the triple crystalline nature of these terpolymers and revealed that they crystallize in sequence: the PLLA block crystallizes first, then the PCL block, and finally the PEO block. Differential scanning calorimetry (DSC) analysis further demonstrated that the three blocks can crystallize from the melt when a low cooling rate is employed. The crystallization process takes place from a homogenous melt as indicated by small angle X-Ray scattering (SAXS) experiments. The crystallization and melting enthalpies and temperatures of both PEO and PCL blocks decrease as PLLA content in the terpolymer increases. Polarized light optical microscopy (PLOM) demonstrated that the PLLA block templates the morphology of the terpolymer, as it forms spherulites upon cooling from the melt. The subsequent crystallization of PCL and PEO blocks occurs inside the interlamellar regions of the previously formed PLLA block spherulites. In this way, unique triple crystalline mixed spherulitic superstructures have been observed for the first time. As the PLLA content in the terpolymer is reduced the superstructural morphology changes from spherulites to a more axialitic-like structure.

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Poly(ethylene oxide) (PEO)-based ABC triblock terpolymers – synthetic complexity vs. application benefits

Cited by 52 publications

References 150 publications

Morphology Transition of Dual‐Responsive ABC Terpolymer in Water: Effect of Hydrophobic Block

Morphology Transition of Dual‐Responsive ABC Terpolymer in Water: Effect of Hydrophobic Block

ABC triblock copolymer-stabilized gold nanoparticles for catalytic reduction of 4-nitrophenol

Sequential crystallization and morphology of triple crystalline biodegradable PEO-b-PCL-b-PLLA triblock terpolymers

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