Poly(ethylene oxide) surfactant polymers

Vacheethasanee, Katanchalee; Wang, Shuwu; Qiu, Ye; Marchant, Roger

doi:10.1163/156856204322752255

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…HA binds specifically to proteins in the extracellular matrix, on the cell surface, within the cellular cytosol, thus having roles in cartilage matrix stabilization, angiogenesis, cell mobility, inflammation regulation and growth factor actions [10,11]. PEO, the other main component of the hydrogel in this study, has been employed as one of the most biocompatible polymers in biomedical materials among synthetic polymers such as constituent polymers for hydrogels, cell non-adhesive polymers and carriers of bioactive molecules in drug delivery systems [12,13]. PEO is known to have outstanding biomedical properties such as biocompatibility, chain mobility, hydrophilicity, protein and cell repellence, no degradation by mammalian enzymes and favorable modification chemistry known as PEGylation [14].…”

Section: Introductionmentioning

confidence: 99%

Effects of cross-linking molecular weights in a hyaluronic acid–poly(ethylene oxide) hydrogel network on its properties

et al. 2006

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We examined the effects of cross-linking molecular weights on the properties of a hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel. Swelling behaviors, mechanical strength and rheological behaviors of the HA-PEO hydrogel were evaluated by employing different cross-linking molecular weights (100 kDa and 1.63 mDa) of the HAs in the hydrogel networks. The low molecular weight of HA was obtained in advance by treating high molecular weight HA with a hydrogen chloride solution. Methacrylation of HA was obtained by grafting aminopropylmethacrylate to its caroboxylic acid functional groups. While reduction of the HA molecular weights was confirmed by gel permeation chromatography, the degree of methacrylate grafting to the HA was measured by (1)H-nuclear magnetic resonance. Synthesis of the HA-PEO hydrogel was successfully achieved via the Michael-type addition reaction between the methacrylate arm groups in the HA and the six thiol groups in PEO. The hydrogel formation was not dependent upon the HA molecular weights and its gelation behaviors were markedly different. Compared to the properties of the high molecular weight HA-based PEO one, the low molecular weight HA-based hydrogel induced quicker hydrogelation, as observed from the behaviors of the elastic and viscous modulus. Furthermore, the low molecular weight HA-based hydrogel demonstrated stronger mechanical properties as measured with a texture analyzer, lower water absorption as measured with a microbalance and smaller pore sizes on its surface and cross section as observed with scanning electron microscopy. The information about the effects of the cross-linking molecular weights of the gel network on the properties of the HA-based PEO hydrogel may lead to better design of hydrogels, especially in tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Effects of cross-linking molecular weights in a hyaluronic acid–poly(ethylene oxide) hydrogel network on its properties

et al. 2006

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“…Trials with collagen and PEO were unsuccessful as cell viability was not acceptable. Highly hydrated polymers, such as PEO, suppress cellular and molecular adhesions by providing a physical steric barrier [35,36].…”

Section: Discussionmentioning

confidence: 99%

Electrospinning Live Cells Using Gelatin and Pullulan

et al. 2020

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Electrospinning is a scaffold production method that utilizes electric force to draw a polymer solution into nanometer-sized fibers. By optimizing the polymer and electrospinning parameters, a scaffold is created with the desired thickness, alignment, and pore size. Traditionally, cells and biological constitutes are implanted into the matrix of the three-dimensional scaffold following electrospinning. Our design simultaneously introduces cells into the scaffold during the electrospinning process at 8 kV. In this study, we achieved 90% viability of adipose tissue-derived stem cells through electrospinning.

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“…Herein, PEO-a water-soluble polymer with eco-friendly and benign properties [30,31]-was proposed as a surfactant to stabilize fiber morphology. Moreover, gelatin-a protein obtained by the hydrolysis of native collagen fibers [32]-was offered as a bioactive agent to improve biocompatibility, promote cell interaction, and mimic the composition of fibrous components of the extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Polyvinyl Alcohol-Based Electrospun Fibers with Bioactive or Electroconductive Phases for Tissue-Engineered Scaffolds

Renkler,

Cruz Maya,

Guarino

2023

Fibers

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The accurate mimicking of the fibrillary structure of the extracellular matrix represents one of the critical aspects of tissue engineering, playing a significant role in cell behavior and functions during the regenerative process. This work proposed the design of PVA-based multi-component membranes as a valuable and highly versatile strategy to support in vitro regeneration of different tissues. PVA can be successfully processed through electrospinning processes, allowing for the integration of other organic/inorganic materials suitable to confer additive bio-functional properties to the fibers to improve their biological response. It was demonstrated that adding polyethylene oxide (PEO) improves fiber processability; moreover, SEM analyses confirmed that blending PVA with PEO or gelatin enables the reduction of fiber size from 1.527 ± 0.66 μm to 0.880 ± 0.30 μm and 0.938 ± 0.245 μm, respectively, also minimizing defect formation. Furthermore, in vitro tests confirmed that gelatin integration allows the formation of bioactive nanofibers with improved biological response in terms of L929 adhesion and proliferation. Lastly, the processability of PVA fibers with conductive phases such as polyvinylpyrrolidone (PVP) or poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) has also been verified. From this perspective, they could be promisingly used to design electroactive composite fibers able to support the regeneration process of electrically stimulated tissues such as nerves or muscles.

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Poly(ethylene oxide) surfactant polymers

Cited by 12 publications

References 23 publications

Effects of cross-linking molecular weights in a hyaluronic acid–poly(ethylene oxide) hydrogel network on its properties

Effects of cross-linking molecular weights in a hyaluronic acid–poly(ethylene oxide) hydrogel network on its properties

Electrospinning Live Cells Using Gelatin and Pullulan

Optimization of Polyvinyl Alcohol-Based Electrospun Fibers with Bioactive or Electroconductive Phases for Tissue-Engineered Scaffolds

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