Poly(glutamic acid): From natto to drug delivery systems

Johnson, Leah C.; Akinmola, Adekunle Titus; Scholz, Carmen

doi:10.1016/j.bcab.2022.102292

Cited by 13 publications

(6 citation statements)

References 60 publications

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“…Glutamate is the highest produced amino acid industrially 25 due to its use in the food sector. 26 Its derivatives, including γbenzyl-L-glutamate NCA (BLG-NCA), are readily available. BLG-NCA affords poly(γ-benzyl-L-glutamate) (PBLG) which is a helical polymer with biomimetic secondary structuring properties, 27 while its deprotected form, polyglutamic acid (PGA), is water-soluble and pH-responsive.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Glutamate is the highest produced amino acid industrially due to its use in the food sector . Its derivatives, including γ-benzyl- l -glutamate NCA (BLG-NCA), are readily available.…”

Section: Resultsmentioning

confidence: 99%

“…BLG-NCA affords poly(γ-benzyl- l -glutamate) (PBLG) which is a helical polymer with biomimetic secondary structuring properties, while its deprotected form, polyglutamic acid (PGA), is water-soluble and pH-responsive . Polymers ,,, and copolymers , of PBLG or PGA derivatives have potential applications in bioactive substance delivery, − and the preparation of antibacterial agents or biomaterials …”

Section: Resultsmentioning

confidence: 99%

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Toward Synthetic Intrinsically Disordered Polypeptides (IDPs): Controlled Incorporation of Glycine in the Ring-Opening Polymerization of N-Carboxyanhydrides

Badreldin,

Salas-Ambrosio,

Bourasseau

et al. 2024

Biomacromolecules

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Intrinsically disordered proteins (IDPs) do not have a well-defined folded structure but instead behave as extended polymer chains in solution. Many IDPs are rich in glycine residues, which create steric barriers to secondary structuring and protein folding. Inspired by this feature, we have studied how the introduction of glycine residues influences the secondary structure of a model polypeptide, poly(L-glutamic acid), a helical polymer. For this purpose, we carried out ring-opening copolymerization with γbenzyl-L-glutamate and glycine N-carboxyanhydride (NCA) monomers. We aimed to control the glycine distribution within PBLG by adjusting the reactivity ratios of the two NCAs using different reaction conditions (temperature, solvent). The relationship between those conditions, the monomer distributions, and the secondary structure enabled the design of intrinsically disordered polypeptides when a highly gradient microstructure was achieved in DMSO.

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Section: ■ Results and Discussionmentioning

confidence: 99%

“…Glutamate is the highest produced amino acid industrially due to its use in the food sector . Its derivatives, including γ-benzyl- l -glutamate NCA (BLG-NCA), are readily available.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Toward Synthetic Intrinsically Disordered Polypeptides (IDPs): Controlled Incorporation of Glycine in the Ring-Opening Polymerization of N-Carboxyanhydrides

Badreldin,

Salas-Ambrosio,

Bourasseau

et al. 2024

Biomacromolecules

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“…15 The prepared CS/γ-PGA CPs have been widely applied in the biomedical and biotechnological applications. 16,17 Furthermore, chitosan and γ-PGA are suitable carbon precursors, and have been use to prepare carbon materials via direct pyrolysis or hydrothermal carbonization methods. 18,19 However, the most of carbon materials fabricated from chitosan and γ-PGA were bulk or microsphere with the diameter of 1-3 μm.…”

Section: Introductionmentioning

confidence: 99%

“…Due to their interesting opposite charges at acidic pH, chitosan and γ‐PGA can self‐assemble to chitosan/γ‐PGA colloidal particles (CS/γ‐PGA CPs) in aqueous solution, via electrostatic interactions 15 . The prepared CS/γ‐PGA CPs have been widely applied in the biomedical and biotechnological applications 16,17 . Furthermore, chitosan and γ‐PGA are suitable carbon precursors, and have been use to prepare carbon materials via direct pyrolysis or hydrothermal carbonization methods 18,19 .…”

Section: Introductionmentioning

confidence: 99%

A fabrication strategy for porous carbon spheres based on cross‐linked chitosan/poly(γ‐glutamic acid) colloidal particles

Sun

Liu

Xu³

et al. 2022

J of Applied Polymer Sci

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A new strategy was developed to prepare nanoscale porous carbon spheres (PCSs) using cross-linked chitosan/poly(γ-glutamic acid) colloidal particles as precursor. The fabricated cross-linked chitosan/poly(γ-glutamic acid) colloidal particles (Ca 2+ /CS/γ-PGA CPs) were prepared from the self-assembly of negatively charged poly(γ-glutamic acid) and positively charged chitosan, and the cross-linking of Ca 2+ in aqueous solution, via the electrostatic interaction. After lyophilization, the Ca 2+ /CS/γ-PGA CPs power was obtained, followed by carbonization in a tube furnace under N 2 atmosphere. Finally, the products were washed by hydrochloric acid, obtaining PCSs with hierarchical pore structure and super-hydrophobicity. The prepared PCSs exhibited excellent separation performance for oil-in-water emulsions.

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Synthetic strategies of short peptide-modified nanomaterials for diagnostics and phototherapy

Khan,

Atiq,

Irshad

et al. 2024

Organic Nanomaterials for Cancer Phototheranostics

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Poly(glutamic acid): From natto to drug delivery systems

Cited by 13 publications

References 60 publications

Toward Synthetic Intrinsically Disordered Polypeptides (IDPs): Controlled Incorporation of Glycine in the Ring-Opening Polymerization of N-Carboxyanhydrides

Toward Synthetic Intrinsically Disordered Polypeptides (IDPs): Controlled Incorporation of Glycine in the Ring-Opening Polymerization of N-Carboxyanhydrides

A fabrication strategy for porous carbon spheres based on cross‐linked chitosan/poly(γ‐glutamic acid) colloidal particles

Synthetic strategies of short peptide-modified nanomaterials for diagnostics and phototherapy

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