Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Abstract

The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.

Catalyst-controlled polycondensation of glycerol with diacyl chlorides: linear polyesters from a trifunctional monomer

“…Poly(glycerol sebacate) (PGS), a biodegradable polyester that has been employed extensively for biomedical applications, 51,52 was selected as the target for optimization of reaction conditions. Based on our reported protocol for monoacylation of di- and triols, we used sebacoyl chloride as the diacid-derived monomer, N , N -diisopropylethylamine (iPr 2 NEt) as base and borinic acids 1a–1c as catalysts (Table 1).…”

Biocompatible, degradable thermoplastic polyurethane based on polycaprolactone-block-polytetrahydrofuran-block-polycaprolactone copolymers for soft tissue engineering

“…Other polyol/dicarboxylic acid based-elastomers that possess low moduli (less than 1 MPa) have been developed especially for soft tissue engineering applications, such as poly(polyol sebacate) (PPS) and poly(glycerol sebacate) (PGS). 37, 38 While they are commonly fabricated as gel scaffolds, they require a polymer carrier in electrospinning. Moreover, crosslinking is also required to maintain the produced architecture.…”

Synthesis, Characterization and 3D Micro-Structuring via 2-Photon Polymerization of Poly(glycerol sebacate)-Methacrylate–An Elastomeric Degradable Polymer

“…This polyester based polymer is produced from non-toxic and relatively low cost monomers (glycerol and sebacic acid) and displays tunable elastomeric mechanical properties, cytocompatibility, and rapid degradation under physiological conditions [1][2][3]. These properties have resulted in PGS being utilized in various soft tissue engineering applications.…”