Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth

Lockhart, Jacob N.; Spoonmore, Thomas J.; McCurdy, Michael W.; Rogers, Bridget R.; Guelcher, Scott A.; Harth, Eva

doi:10.1021/acsami.7b15981

Cited by 18 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Taking into account the potential biomedical applications, PGL and PEO are reported to be similar regarding biocompatibility 29 , and PGL-grafted surfaces were reported to resist protein adsorption 30,31 and biofilm growth. 32 Nevertheless, the protein adsorption onto PGL-stabilized nanoparticles (spherical surfaces) was never explored to the best of our knowledge. Therefore, we consider of due relevance the investigations regarding protein adsorption onto PGL-stabilized nanoparticles since such polymers can be thought as a promising solution to overcome the limitations of other polymers (including PEG).…”

Section: Introductionmentioning

confidence: 99%

Polyglycidol-Stabilized Nanoparticles as a Promising Alternative to Nanoparticle PEGylation: Polymer Synthesis and Protein Fouling Considerations

Oliveira

Albuquerque

et al. 2020

Langmuir

View full text Add to dashboard Cite

We herein demonstrate the outstanding protein-repelling characteristic of starlike micelles and polymersomes manufactured from amphiphilic block copolymers made by poly(butylene oxide) (PBO) hydrophobic segments and polyglycidol (PGL) hydrophilic outer shells. Although positively charged proteins (herein modeled by lysozyme) may adsorb onto the surface of micelles and polymersomes where the assemblies are stabilized by short PGL chains (degree of polymerization smaller then 15), the protein adsorption vanishes when the degree of polymerization of the hydrophilic segment (PGL) is higher than ~ 20, regardless the morphology. This has been probed by using three different model proteins which are remarkable different concerning molecular weight, size and zeta potential (bovine serum albumin -BSA, lysozyme and immunoglobulin G -IgG). Indeed, the adsorption of the most abundant plasma protein (herein modeled as BSA) is circumvented even by using very short PGL shells due to the highly negative zeta potential of the produced assemblies which presumably promotes protein-nanoparticle electrostatic repulsion. The highly negative zeta potential, on the other hand, enables lysozyme adsorption and the phenomenon is governed by electrostatic forces as evidenced by isothermal titration calorimetry.Nevertheless, the protein coating can be circumvented by slightly increasing the degree of polymerization of the hydrophilic segment. Notably, the PGL length required to circumvent protein fouling is significantly smaller than the one required for PEO. This feature and the safety concerns regarding the synthetic procedures on the preparation of poly(ethylene oxide)-based amphiphilic copolymers might make polyglycidol a promising alternative towards the production of non-fouling particles.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyglycidol-Stabilized Nanoparticles as a Promising Alternative to Nanoparticle PEGylation: Polymer Synthesis and Protein Fouling Considerations

Oliveira

Albuquerque

et al. 2020

Langmuir

View full text Add to dashboard Cite

show abstract

“…By adding 6 wt % EGCG, live bacteria are barely visible. These in vitro antibacterial results prove that the antibacterial ability of EGCG/UHMWPE blends is realized by the in situ released EGCG and immobilized EGCG to eliminate both planktonic bacteria and adhesive bacteria. , …”

Section: Resultsmentioning

confidence: 52%

“…These in vitro antibacterial results prove that the antibacterial ability of EGCG/UHMWPE blends is realized by the in situ released EGCG and immobilized EGCG to eliminate both planktonic bacteria and adhesive bacteria. 42,43 ATP is a basic energy unit in cells that maintains biological activities. 44 The leakage of ATP declares cytolysis of the bacteria cells.…”

Section: Resultsmentioning

confidence: 99%

Polyphenol-Assisted Chemical Crosslinking: A New Strategy to Achieve Highly Crosslinked, Antioxidative, and Antibacterial Ultrahigh-Molecular-Weight Polyethylene for Total Joint Replacement

Ren

Wang

Lan

et al. 2020

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Highly crosslinked ultrahigh-molecular-weight polyethylene (UHMWPE) bearings are wear-resistant to reduce aseptic loosening but are susceptible to oxidize in vivo/in vitro, as reported in clinical studies. Despite widespread acceptance of antioxidants in preventing oxidation, the crosslinking efficiency of UHMWPE is severely impacted by antioxidants, the use of which was trapped in a trace amount. Herein, we proposed a new strategy of polyphenol-assisted chemical crosslinking to facilitate the formation of a crosslinking network in high-loaded tea polyphenol/UHMWPE blends. Epigallocatechin gallate (EGCG), a representative of tea polyphenol, was mixed with UHMWPE and peroxide. Multiple reactive phenolic hydroxyl groups of tea polyphenol coupled with the nearby free radicals to form extra crosslinking sites. The crosslinking efficiency was remarkably enhanced with increasing tea polyphenol content, even at a concentration of 8 wt %. Given by the hydrogen donation principle, the high-loaded tea polyphenol also enhanced the oxidation stability of the crosslinked UHMWPE. The antioxidative performance was preserved even after tea polyphenol elution. Moreover, superior antibacterial performance was achieved by the in situ tea polyphenol release from the interconnected pathways in the present design. The strategy of polyphenol-assisted chemical crosslinking is applicable for producing highly crosslinked, antioxidative, and antibacterial UHMWPE, which has promising prospects in clinical applications.

show abstract

“…A hyper-branched polyglycidol (HBPG) with a high degree of branching (DB) has attracted increasing attention from both academia and industry because of its biocompatibility, versatility, hydrophilicity, and high number of available functional groups, and its feasibility to use as alternatives to dendrimers and star polymers for various applications including drug delivery systems. − The semi-branched polyglycidol (SBPG) with a low DB is also attractive as a hydrogel substrate and a coating biomaterials because of the enhanced thermal stability, ability to form hydrogen bonds, and possibility to derivatize their primary alcohol. − Extensive studies have been undertaken to control the macromolecular structure of the resultant polyols . The ring-opening multibranching polymerization (ROMBP) of latent cyclic AB 2 -type monomers is a key reaction to achieve a wide variety of polyglycidols as well as complex macromolecular architectures. − …”

Section: Introductionmentioning

confidence: 99%

Kinetic and Mechanistic Study of Heterogeneous Double Metal Cyanide-Catalyzed Ring-Opening Multibranching Polymerization of Glycidol

et al. 2020

View full text Add to dashboard Cite

Polyglycidols of tunable degree of branching (DB) have been synthesized via ring-opening multibranching polymerization (ROMBP) of glycidol in the absence of any initiators using heterogeneous double metal cyanide (DMC) catalysts. Semi-branched polyglycidols of low DB (less than 0.3) are obtained using simple solvent-free batch polymerizations, whereas hyperbranched analogues of high DB (more than 0.5) are achieved employing semi-batch (or slow monomer addition) polymerizations. The rate of DMC-catalyzed ROMBPs of glycidol shows the first-order dependences on monomer and catalyst concentrations, suggesting that the ROMBPs proceed via a coordinative mechanism. The formation of propagating species and the resultant microstructural units are clarified using a conversion versus time analysis in the NMR-scale.

show abstract

Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth

Cited by 18 publications

References 25 publications

Polyglycidol-Stabilized Nanoparticles as a Promising Alternative to Nanoparticle PEGylation: Polymer Synthesis and Protein Fouling Considerations

Polyglycidol-Stabilized Nanoparticles as a Promising Alternative to Nanoparticle PEGylation: Polymer Synthesis and Protein Fouling Considerations

Polyphenol-Assisted Chemical Crosslinking: A New Strategy to Achieve Highly Crosslinked, Antioxidative, and Antibacterial Ultrahigh-Molecular-Weight Polyethylene for Total Joint Replacement

Kinetic and Mechanistic Study of Heterogeneous Double Metal Cyanide-Catalyzed Ring-Opening Multibranching Polymerization of Glycidol

Contact Info

Product

Resources

About